Platinum nanoparticles have shown to have a remarkable antioxidant activity. Growing evidence between oxidative stress and bone loss suggests that platinum nanoparticle could protect bone loss via modulating oxidative stress. Intragastrical administration of platinum nanoparticle reduced ovariectomy (OVX)-induced bone loss with lowered level of in vivo bone resorption. Platinum nanoparticle inhibited osteoclast (OC) formation via an impaired receptor activator of nuclear factor-κB ligand (RANKL) signaling due to reduced reactive oxygen species. Our data clearly highlights the potential of platinum nanoparticle for amelioration of bone loss after estrogen deficiency via delayed OC formation.
This work was supported by a KHIDI Grant (A111295), KRF Grants (BRL 20090087350; 20100002644) funded by the Korean government.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.
05 - 09 May 2012
European Society of Endocrinology