The effect of radio-iodine treatment on Helicobacter pylori eradication
A. Usluogullari1, S. Caner1, E. Ozdemir1, E. Onal1, O. Ersoy2, R. Ersoy2 & B. Cakir2
Aim: Radioactive treatment after surgery forms the basis of treatment of differentiated thyroid cancers (DTC) and also used as permanent theraphy of hyperthyroidism. Iodide is being transported into the thyrocytes by the NIS system that located on the thyrocytes cell membran. NIS system also has been shown at the gastric mucosa. In this study we proposed to analyse the effect of low and high dose radio-iodine treatment on Helicobacter pylori eradication.
Material and methods: Total 87 patients included for study. The patients investigated detailed about medications and gastrointestinal symptoms. Patients have neither dyspeptic symptoms nor any usage of H2 receptor bloker, proton pump inhibitor, antiasit or any form of antibiotics. Urea breath test before and 2 months after radio-iodine treatment have been made for detection of Helicobacter pylori eradication.
Results: The radio-iodine treatment has been planned to give as permanent threapy to 76 patient (87.4%) with hyperthyroidism and 11 patient (12.6%) with differantial thyroid cancer. The average dose of given radio-active iodine to patients for ablation purposes is 115±3.3 and 22.7±1.4 mCi. Before RAI treatment, in the group of DTC the urine breath test result of the 44 patients had positive HP and 32 of them had negative HP, and for hyperthyroid patients four of them had positive HP and seven of them had negative HP. All patients having initial positive test results had also positive control test results at the 2nd month of the RAI treatment (100%). Both patient group having initial negative test results, had also negative control test results (100%).
Conclusion: There are some literature studies shows that RAI treatment is effective on HP eradication. Our results indicate that low and high dosage of RAI treatment does not have any effect on HP eradication in early period.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.