Evaluation of clinical and laboratory findings of our primary hyperparathyroid patients
H. Baser1, D. Tuzun1, A. Usluogullari1, C. Aydin1, R. Ersoy2 & B. Cakir2
Aim: In this study our aim was to evaluate clinical and laboratory findings of our primary hyperparathyroid patients and detect complications caused by hyperparathroidism.
Method: Eighty-three patients (73 women, 10 men) were included in this study. Serum calcium (Ca), phosphorus (P), parathormone (PTH), 25(OH) D, 24 hour urine Ca and P levels, bone mineral density (BMD) and renal ultrasonography were evaluated.
Results: The mean age at diagnosis was 52.4±9.6 years. The mean serum Ca level was 10.47±0.67 mg/dl, serum P level was 2.85±0.50 mg/dl, PTH level 254.12±140.72 pg/ml, 25-OH vitamin D3 level was 22.97±16.15 μg/l. Serum Ca was <11 mg/dl in 66 patients (%19.3), 1112 mg/dl in 16 patients, >12 mg/dl in one patient. Mean 24 hour urine Ca was 354.52±177.23 mg/day, P was 868.42±385.86 mg/day. Hypercalciuria was detected in 27 patients (%32.5) while nephrolithiasis was determined in 17 patients (%20.5). In 16 patients (%19.3) BMD was normal. In 31 patients (%37.3) osteopenia, in 36 patients (%43.4) osteoporosis was determined. Vit D deficiency was found in 38 patients (%45.8). With these results operation was recommended to 44 patients (%47).
Conclusion: In recent years primary hyperparathyroidism is detected in asymptomatic phase and fewer complications are found. One of the factors that contribute to low bone density in patients with hyperparathyroidism may be lack of Vit D.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.