Cystatin levels in diabetic and prediabetic patients
S. Akin1, N. Ersoz Gulcelik3, D. Yazgan Aksoy2, J. Karakaya4, M. Bayraktar1 & A. Usman1
Background and aim: Serum Cystatin C has been shown to be associated with the progression to prediabetes and type 2 diabetes mellitus. High cystatin levels were also found to be associated with body mass index. The aim of this study was to evaluate cystatin C levels in diabetic and prediabetic patients ant its association with anthropometric measurements and insulin resistance.
Methods: Twenty four patients with diabetes, 17 patients with prediabetes and 24 healthy controls were included in the study. Age, weight, body mass index, waist circumference (Wc), fasting plasma glucose (FPG), post pyrandial glucose (PPG), lipid profiles, blood urea nitrogen (BUN) and creatinine levels were measured. None of the patients had any diabetic complications.
Results: Diabetic patients had higher BMI than controls (P=0.01). Serum cystatin C levels were not statistically different between the three groups (P>0.05) and were similar in men and women. Cystatin C levels were correlated with body mass index and HOMA IR in prediabetic patients (P=0.039 and P=0.05, repectively)) but not in diabetic patients and controls, when adjusted for age and gender.
Conclusions: Serum cystatin C levels are associated with body mass index and insulin resistance in prediabetic patients.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.