Relationship between serum levels of 1-84 parathormone (PTH1-84) and obesity, HOMA insulin-sensitivity or beta-cells function (HOMA-B) in type 2 diabetic patients
M. Belovici1 & M. Buysschaert2
Introduction: PTHrP (Parathyroid hormone-related protein) is known to enhance beta cell function and proliferation. PTH levels predict myocardial and coronary heart disease in non-diabetic patients with normal calcium levels and no kidney failure. We aimed at determining in type 2 diabetes patients without kydney failure the relationship between serum levels of 1-84 parathormone (PTH1-84), obesity, HOMA insulin-sensitivity or beta-cells function (HOMA-B), but also between PTH1-84 and confirmed myocardial arterial disease (MAD).
Research design and methods: 106 adult patients with type 2 diabetes were divided into two groups: group A - absent myocardial arterial disease (n=64) and group B- confirmed myocardial arterial disease (n=42). The groups were matched regarding age, HbA1c, body mass index (BMI), glomerular filtration rate, microalbuminuria, vitamin D.
Conclusion: In type 2 diabetic patients, obesity, insulin resistance and poor control of diabetes are positively associated with increased levels of PTH. Parathormone may contribute to the development of systolic dysfunction and myocardial heart disease. In this regard, treating the hypovitaminosis D in type 2 diabetic patients can improve the cardiovascular protection. In the same time, we found a positive correlation between PTH1-84 and beta-cells function suggesting a role for PTH1-84 in insulin secretion.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector