The effects of fat distribution and some adipokines on insulin resistance in prediabetic patients
B Ekiz Bilir, S Guldiken, N Tuncbilek, M Demir & A Polat
Introduction: In this study, we aimed to evaluate the effects of fat distribution and some adipokines on insulin resistance (IR) in prediabetic patients.
Materials and Methods: cases were divided into three groups according to 75 gr-oral glucose tolerance test (OGTT) results [27 cases impaired fasting glucose (IFG), 36 cases impaired glucose tolerance (IGT) and 24 healthy control subjects]. Serum fasting insulin levels and lipid parameters were measured. Homeostatic model assessment of insulin resistance (HOMA-IR) was calculated. Body fat mass measurements were assessed by TANITA. Abdominal fat distributions (visceral, subcutaneous, preperitoneal fat thickness) were evaluated by ultrasonography. The fasting serum levels of adipokines [adiponectin, leptin, resistin, vaspin, visfatin, retinol-binding protein 4 (RBP4), tumor necrosis factor-α (TNF-α)] were measured by ELISA method.
Results: There were no differences between groups in terms of the age, sex, body mass index (BMI), mean insulin, lipid parameters, vaspin, RBP4, leptin, resistin, TNF-α, abdominal fat distributions, fat mass measurements. There were significant differences between groups in terms of HOMA-IR values, adiponectin and visfatin (NGT-IFG groups P>0.05, P<0.001, P<0.05; NGT-IGT groups P<0.05, P<0.01, P<0.001 respectively). There was significant correlation between HOMA-IR and BMI values (r=0.367, P<0.01), waist circumference (r=0.361, P<0,05), OGTT 2nd hour-glucose (r=0.282, P<0.05), total fat percentage (r=0.308, P<0,05), total fat mass (r=0.411, P<0.01), visceral fat thickness (r=0.395, P=0.01), adiponectin (r=−0.322, P<0.05) and resistin (r=0.245, P=0.05) levels in the prediabetic group. In regression analysis, visceral fat thickness was found to be an independent risk factor for development of insulin resistance (P<0.001, B=0.438, 95% CI 0.010.039).
Conclusion: In this study, we concluded that adiponectin and resistin affected the insulin resistance in prediabetic patients and especially the increments in visceral fat thickness had negative effects on insulin resistance.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.