Diabetic nephropathy and risk factors associated with DM in newly diagnosed type 2 diabetics
Y. Themeli1,3, V. Bajrami1, M. Barbullushi2,3, A. Idrizi2, D. Teferici3, L. Muka1 & E. Ktona3
Objective: Nephropathy is a common complication in diabetes mellitus (DM), with significant morbidity and mortality. Diabetic nephropathy (DN) is more likely to develop in the presence of some risk factors associated with type 2 diabetes mellitus, even in newly diagnosed diabetics.
Aim: To study the incidence of diabetic nephropathy in newly diagnosed type 2 diabetics and to study the relationship of development of nephropathy with various risk factors associated with DM, like age, sex, blood pressure, blood sugar and body mass index (BMI).
Material and methods: We analysed 100 newly diagnosed type 2 diabetics (diagnosed within 2 years), between September 2008 to October 2010. Presence of urinary microalbuminuria in two samples in a period of 6 months was taken as criteria for detecting nephropathy.
Results: Incidence of DN in newly diagnosed type 2 diabetics was 15% (15/100). This incidence had significant correlation with age, increasing significantly with increase in age (33% in age group >60 years). Also, DN resulted more frequent in male sex and high blood pressure, with incidence of nephropathy being as high as 8% at BP>160/100 mmHg (P=0.001). The incidence of DN also increased with increase in BMI as well as HbA1c. Dyslipidemia also significant effect, especially hypertrigliceridemy (P=0.01). The familly history of DM didnt result significantly important in development of DN.
Conclusion: Incidence of DN in newly diagnosed type 2 diabetics is as high as 15%. Hypertension is the most important associated factor contributing to development of nephropathy in these patients. Age over 60 years old, male sex, poor glycemic control, high BMI and dyslipidemia play significant role.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.