Plasma anti-Müllerian hormone concentration in women with polycystic ovary syndrome and type 1 diabetes mellitus
A. Lebkowska1, M. Karczewska-Kupczewska1, A. Nikolajuk1,2, A. Adamska1, E. Otziomek1, S. Wolczynski1, M. Gorska1 & I. Kowalska1
Introduction: A high prevalence of polycystic ovary syndrome (PCOS) and hyperandrogenism has been described in adult women with type 1 diabetes mellitus (T1DM). Anti-Müllerian hormone (AMH) is secreted by granulosa cells of antral ovarian follicles and its plasma concentration is correlated with the number of small antral follicles. AMH levels are increased in women with PCOS and higher plasma concentration has been observed in prepubertal girls with T1DM. The aim of this study was to estimate plasma AMH concentrations in women with PCOS with and without T1DM and its relation to hormonal profile.
Study participants and methods: We studied seven women with PCOS and T1DM (T1DM+PCOS), seven women with PCOS without T1DM (PCOS), 10 women with T1DM without PCOS (T1DM), and eight healthy women (control). The clinical examination, estimation of plasma AMH, sex hormones and ultrasonographic evaluation were performed in all study participants.
Results: Plasma AMH concentration was markedly higher in PCOS group vs controls (P=0.041) and was not different between T1DM+PCOS and control group, and both PCOS group (PCOS vs T1DM+PCOS). Plasma SHBG was higher in T1DM+PCOS in comparison to PCOS (P=0.024). Ovarian volume and follicles number were higher in PCOS and T1DM+PCOS vs controls (P=0.013, P=0.045 and P=0.029, P=0.011 respectively). T1DM+PCOS had increased plasma AMH concentration (P=0.011), higher ovarian volume and follicles number vs diabetic women without PCOS. In the entire studied group plasma AMH correlated significantly with FSH (r=−0.385, P=0.03), testosterone (r=0.434, P=0.013) and number of ovarian follicles (r=0.705, P<0.0001).
Conclusion: Obtained results suggest that AMH might be involved in pathogenesis of PCOS in type 1 diabetic patients.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This work was supported, however funding details unavailable.