Increased risk of glucose metabolism impairment after gestational diabetes in polycystic ovary syndrome
F. Orio1,2, A. Colao3, A. Falbo4, T. Russo4, M. Orio5, R. Vero6, C. Capula6, A. Volpe5, V. Di Stasi5, S. Savastano3, G. Lombardi3 & S. Palomba4
Objective: The aim of the present study was to test the hypothesis that the risk of persistent glucose impairment after gestational diabetes (GDM) is increased in patients with polycystic ovary syndrome (PCOS).
Research design and methods: The prospective casecontrol study included 42 pregnant patients with PCOS and GDM and 84 pregnant control patients with GDM but without clinical and biochemical hyperandrogenism, polycystic ovaries and oligo-anovulation. The cases and controls were matched one to two for age and body mass index. The glycemic profiles were studied in all subjects 6 weeks, 12 weeks and 18 months after delivery. The incidence and the relative risk (RR) were calculated for overall persistence of an abnormal glycemic pattern and for each specific alteration, i.e. impaired glucose tolerance (IGT), impaired fasting glucose (IFG), and diabetes mellitus (DM).
Results: At 18 months after delivery, the incidences of IFG, IGT and IFGIGT were significantly (P<0.05) higher in the cases than in the controls. At the 18-month follow-up, the RR for the composite outcome of glucose metabolism impairment in PCOS women was 3.45 (95% confidence interval (CI) 1.826.58).
Conclusions: Patients with PCOS are at increased risk for a persistent impaired glucose metabolism after GDM.
Declaration of interest: The authors declare that there is no conflict of interest that could be perceived as prejudicing the impartiality of the research project.
Funding: This research did not receive any specific grant from any funding agency in the public, commercial or not-for-profit sector.