Endocrine Abstracts (2015) 37 EP849 | DOI: 10.1530/endoabs.37.EP849

Recurrent bone metastasis of follicular thyroid carcinoma with unknown primary site

Ji Oh Mok1, Chong Hwa Kim2, Sung Rae Kim3, Seung Hee Yu4 & Kiyoung Lee4


1Soonchunhyang University Bucheon Hospital, Bucheon, Republic of Korea; 2Sejong General Hospital, Bucheon, Republic of Korea; 3The Catholic University of Korea Bucheon ST.Mary’s Hospital, Bucheon, Republic of Korea; 4Gachon University Gil Hospital, Incheon, Republic of Korea.


Introduction: Occurrence of follicular thyroid carcinoma (FTC) is limited almost within thyroid gland, but distant metastasis is discovered uncommonly as first presentation. We experienced a rare case about recurrent bone metastasis of FTC with unknown primary site.

Case report: A 58-year-old woman complained about back pain for 3 years. A 5 cm sized mass in right 8th posterior rib was discovered and performed resection. The result of pathology was bone metastasis of FTC. Thirty four years ago, she underwent right thyroidectomy because of benign nodule. Thyroid USG shows no specific findings on remained left lobe of thyroid gland, but PET-CT presents increased uptake in the left thyroid gland, bilateral hilar and mediastinal regions, and right 8th rib. Left thyroid gland was removed totally, but primary FTC wasn’t discovered in left lobe. After operation, she received radioactive iodine (RAI) ablation with 100 mCi. However, recurrent bone metastasis of right 8th posterior rib was found in PET-CT at 6 months after surgery. Repeated operation was performed for the lesion of right rib and pathological finding shows the same results as the first operation. Because of repeated bone metastasis and increased Tg level, she was ablated four times totally with 550 mCi and underwent recurrent operations for bone metastasis of right rib. One year later, metastasis of left temporal bone was found newly and removed surgically with cranioplasty. The result of pathology was a metastasis of FTC such as the previous result. Currently, the patient is followed up in the outpatient department for conservative treatment.

Conclusions: With unknown primary site, recurrent bone metastasis of FTC is a rare case and should be treated with appropriate therapy because of poor prognosis. We report a case about recurrent bone metastasis of FTC managed with repeated operation and RAI ablation.

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