Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2015) 37 EP847 
| DOI:10.1530/endoabs.37.EP847
|

Primary thyroid lymphoma: a heterogeneous disease and presentation of two different cases

Eleni Triantafillou, Georgios Papadakis, Ioannis Keramidas, Konstantinos Moustakas, Georgios Tsakonas, Paraskevi Manitarou, Aspasia Drosou, Olympia Tzaida, Athanasia Tertipi, Ioannis Tzaves, Aikaterini Megalakaki & Anastasios Pappas

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Background: Primary thyroid lymphoma (PTL) is a rare thyroid malignancy. Nevertheless, it frequently presents diagnostic and therapeutic challenges. We describe two patients with PTL with different clinical presentation/clinical picture and outcome.

Patients and methods: Two female patients underwent total thyroidectomy, the first, a 67-year-old female patient, because of nodular goitre and the second, a 79-year-old female patient, because of a large, painless thyroid mass accompanied by severe obstructive symptoms of the upper respiratory and gastrointestinal track.

Results: Histology of the first patient revealed lymphocytic thyroiditis and a small focus of previously unsuspected PTL, coexistent with an occult papillary thyroid carcinoma (PTC). The PTL was an incidental finding and 2 years after thyroidectomy she is free of disease without any further treatment. Histology of the second patient confirmed the clinical suspicion of PTL and established the diagnosis of a diffuse large B-cell lymphoma. Although she underwent standard chemotherapy, she died four months later.

Conclusions: PTL may have an aggressive and lethal course on the one end of the spectrum and the other one may be quite indolent. Our two cases confirm the heterogeneous nature of PTL.

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