ECE2016 Guided Posters Thyroid - Translational & Clinical (1) (10 abstracts)
Evaluation of the interrelations between thyroid function, insulin resistance, lipid profile, C-reactive protein and homocysteine in patients with autoimmune thyroiditis
Celestino Neves 1 , João Sérgio Neves 1 , Sofia Castro Oliveira 1 , César Esteves 1 , Oksana Sokhatska 2 , Camila Dias 3 , Luís Delgado 2 , José Luís Medina 1 & Davide Carvalho 1,
1Department of Endocrinology, Diabetes and Metabolism, São João Hospital Center; Faculty of Medicine of the University of Porto (FMUP), Porto, Portugal; 2Immunology Department, São João Hospital, Faculty of Medicine of University of Porto, Porto, Portugal; 3Department of Health Information and Decision Sciences, São João Hospital, Faculty of Medicine of University of Porto, Porto, Portugal; 4Instituto de Investigação e Inovação em Saúde, University of Porto, Porto, Portugal.
Introduction: In patients with autoimmune thyroiditis, thyroid function appears to be related to increased cardiovascular risk. It was our objective to evaluate the relationship between TSH, insulin resistance, lipid profile, C-reactive protein (CRP) and homocysteine in patients with autoimmune thyroiditis (AIT).
Methods: We analyzed the lipid profile, the CRP, anti-thyroid antibodies, homocysteine, folic acid, vitamin B12 levels and the insulin resistance indexes such as HOMA-IR, QUICKI (Quantitative Insulin Sensitivity Check Index), HISI (Hepatic Insulin Sensitivity Index), WBISI (Whole-Body ISI) and IGI (Insulinogenic Index), in 171 patients with AIT and TSH <2.00 μUI/ml and in 71 patients with AIT and TSH >2.00 μUI/ml. All patients had normal levels of FT3 and FT4. The statistical analysis was done with the Student’s t-test and Pearson correlation. The results are in mean±DP. We considered a two-tailed P-value of <0.05 significant.
Results: We found significantly higher levels of insulin at 120 min of OGTT in the patients with TSH >2.00 μUI/ml (65.9±57.8 vs 84.1±65.4 μUI/ml; P=0.02). The levels of homocysteine were also significantly higher in the group with TSH >2.00 μUI/ml (10.8±12.6 vs 8.3±3.3 μmol/l; P=0.04). We found the IGI (0.036±0.378 vs 0.252±0.310; P=0.02) and WBISI (6.323±7.335 vs 6.112±4.019; P=0.003) indexes to be significantly higher in the TSH >2.00 μUI/ml group. In the group with TSH <2.00 μUI/ml there were positive correlations between IGI and the triglyceride levels (r=0.256; P=0.004) and the anti-TPO levels (r=0.137; P=0.03). In the same group we found negative correlations between WBISI and CRP (r=−0.199; P=0.02) and positive correlations between WBISI and TSH (r=0.44; P=0.01). In the group with TSH >2.00 μUI/ml we found positive correlations between the FT4 levels and the BMI (r=0.413; P<0.001). In the same group the levels of LDL were positively correlated with TSH (r=0.245; P=0.04), and negatively with FT3 (r=−0.265; P=0.02). There was also a positive correlation between the Lp(a) and FT4 levels (r=0.259; P=0.04).
Conclusion: In patients with AIT, the relationship between thyroid function, lipid profile, homocysteine and the insulin resistance indexes, may contribute to an increased cardiovascular risk.
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more