ECE2016 Eposter Presentations Cardiovascular Endocrinology and Lipid Metabolism (51 abstracts)
Metabolic effects by H. pylori infection and eradication
Isabel M Cornejo-Pareja 1 , M Mar Roca-Rodríguez 2, , Leticia Coín-Arangüez 3, , María Molina-Vega 1 , Cristina Díaz-Perdigones 1 , Carmen Hernández-García 1 , Araceli Muñoz-Garach 1 , Juan Alcaide-Torres 4 , Carlos Clu-Fernández 1 , Laura Viñuela-González 5 , Laura Mora-Navas 5 , Isabel Mancha-Doblas 1 & Francisco J Tinahones-Madueño 1
1Endocrinology and Nutrition Department, Virgen de la Victoria Hospital, Málaga, Spain; 2Endocrinology and Nutrition Department, Línea de la Concepción Hospital, Cádiz, Spain; 3Biomedical Research Center of Physiopathology of Obesity and Nutrition (CIBER CB06/003), Carlos III Health Institute, Madrid, Spain; 4Research laboratory IBIMA, Málaga, Spain; 5Microbiology Department, Virgen de la Victoria Hospital, Málaga, Spain.
Introduction: H. pylori infection has been related with diseases such as type 2 diabetes and metabolic syndrome.
Objective: To evaluate changes in carbohydrates metabolism, lipid profile and intake regulating hormones induced by 75 g oral glucose tolerance test (OGTT), before and after antibiotic eradication treatment in patients colonized by H. pylori.
Materials and methods: A prospective study of 40 non-diabetics patients were performed. We analyzed clinical data, carbohydrate and lipid metabolim, and ghrelin and GLP1 levels before and after antibiotic eradication treatment.
Results: We studied 40 patients (60% women). Average age was 46.9±2; 70% had family history of digestive disorders and 57.5% clinical history of gastrointestinal disease (12.5% gastroesophageal reflux disease and 12.5% peptic ulcer). After antibiotic treatment, we found a significant decrease in HbA1c (P=0.014), glucose at 60′ (P=0.018) and 120′ (P=0.019) post-OGTT, and a significant increase in HDL-cholesterol (P=0.021). There were significant changes in basal ghrelin levels (P=0.05). We did not find significant changes in anthropometrics parameters, blood pressure and C-peptide levels. We found some significant positive correlations between weight and BMI with C-peptide, basal glucose and insulin, glucose 120′ post-OGTT pre- and post-treatment; also between triglycerides with HbA1c, C-peptide, glucose and insulin 120′ post-OGTT pre-treatment; and between total-cholesterol with basal glucose and insulin pre and post-treatment. Triglycerides and HDL-cholesterol correlated negatively. We did not find significant correlations between ghrelin leves or GLP-1 with metabolic parameters pre- or post-treatment; 90% of patients completed correctly the treatment and 31.6% used ranitidine although 97.5% got H. pylori eradication after conventional antibiotic treatment.
Conclusions: 1) H. pylori eradication improved carbohydrate and lipid metabolism. 2) Significant correlations between anthropometric measurements, carbohydrates and lipids metabolism before and after treatment were observed. 3) More than 95% of patients achieved H. pylori eradication with conventional antibiotic treatment.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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