Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 EP236 | DOI: 10.1530/endoabs.41.EP236

ECE2016 Eposter Presentations Cardiovascular Endocrinology and Lipid Metabolism (51 abstracts)

Effects of statins on lipid and carbohydrate metabolism in patient with type 2 diabetes and cardiovascular diseases

Boris Mankovsky , Iryna Kondratska & Aleksandra Briukhova


P.L. Shupyk National Medical Academy of Post-graduate Education, Kyiv, Ukraine.


Patients with diabetes mellitus (DM) type 2 is a group of high cardiovascular risk. The incidence of coronary heart disease in their 2–4 times higher than in the population without diabetes, 80% of cases of diabetes combined with hypertension. At the same time any change in lipid metabolism leads to increased cardiovascular risk in patients with type 2 diabetes. Statins is first-line drugs in patients with dyslipidemia.

Materials and methods: The study involved 15 patients with type 2 diabetes and dyslipidemia in mean age 59.8±1.03 years, among them, 11 women and four male. All patients was prescribed statins in mean dose 4 mg per day for 3 month. During the study were determined the levels of glycated hemoglobin (HbA1c) and lipid status before and after treatment.

Results: Analyzing the results obtained in the groups of patients a significant decrease in levels of total cholesterol, low-density lipoprotein. Triglyceride levels decreased to normal range after 3 months. Statistically significant increase in glycated hemoglobin was not confirmed.

Total cholesterolTriglyceridesLow-density lipoproteinVery low density lipoproteinsHigh-density lipoproteinHbA1c, %
Before treatment (n=15)5.64±0.21.77±0.23.73±0.20.51±0.051.49±0.087.39±0.4
After treatment (n=15)4.38±0.2*1.65±0.22.53±0.2>*0.51±0.061.48±0.087.54±0.3
*Significant difference between the indices before and after treatment (P<0.05).

Conclusions: Application of statin leads to the likely reduction in levels of total cholesterol, low density lipoprotein, indicating that effective treatment of dyslipidaemia in patients with type 2 diabetes. Statistically significant effect on glycated hemoglobin was not observed.

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