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Endocrine Abstracts (2016) 41 EP325 | DOI: 10.1530/endoabs.41.EP325

National Institute of Nutrition, Tunis, Tunisia.


Introduction: TSH-secreting pituitary adenomas are rare pituitary functioning tumors accounting for <2% of the pituitary adenomas. Their association to meningiomas is a very rare condition.

We report a case of 55-year-old woman who had multinodular goiter with mild symptoms of hyperthyroidism. Blood tests showed inappropriate secretion of TSH and magnetic resonance imaging (MRI) revealed a pituitary tumor with maximum diameter of 13 mm that was extirpated through transsphenoidal route. After operation fT4 levels were still high and MRI showed persistence of residual tumor and a right parasagittal meningioma was detected. Treatment options are discussed.

Conclusion: Association of meningioma to TSH secreting adenoma is rare but can make difficult the treatment of persistence adenoma. Radiotherapy as well as somatostatin receptors agonists can stimulate the growth of meningioma.

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