Searchable abstracts of presentations at key conferences in endocrinology
Endocrine Abstracts (2016) 41 EP466 | DOI: 10.1530/endoabs.41.EP466

ECE2016 Eposter Presentations Diabetes (to include epidemiology, pathophysiology) (83 abstracts)

Influence of hypercalcemia and elevated parathyroid hormone level in the development of type 2 diabetes

Elena Brutskaya-Stempkovskaya 1, & Alla Shepelkevich 1


1Belarusian State Medical University, Minsk, Belarus; 2Minsk City Polyclinic N31, Minsk, Belarus.


Status of carbohydrate metabolism in patients with primary hyperparathyroidism (PGPT) has been studied extensively in recent years, but the results of studies on the impact of long-term elevated levels of parathyroid hormone and hypercalcemia on the risk of type 2 diabetes continues to be in the discussion.

Objective: To study is to examine the prevalence of type 2 diabetes in patients with manifested and asymptomatic PGPT.

Materials and methods: General clinical examination of 136 patients with PGPT (note the presence of type 2 diabetes, available at diagnosis PGPT and developed in the period from diagnosis to surgical treatment PGPT), investigated parathyroid hormone, vitamin D and calcium.

Results: The asymptomatic PGPT reported in 54 patients (a mean age was 51.5±11.6 years), manifested PGPT - 82 patients (a mean age was 52±10.4 years). Type 2 diabetes is detected in 2 (3.7%) patients with asymptomatic PGPT and 12 persons (14.3%) with the manifested PGPT.

Significant differences was detected in the prevalence of type 2 diabetes in both groups of patients with PGPT (F=0.81, P<0.05).

Conclusion: The results of the study show an increasing prevalence of type 2 diabetes in patients with manifested PGPT compared with asymptomatic PGPT. The results may indicate the influence of long-term hypercalcemia and elevated levels of parathyroid hormone in the frequency of manifestation of type 2 diabetes in patients with PGPT.

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