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Endocrine Abstracts (2016) 41 EP562 | DOI: 10.1530/endoabs.41.EP562

1Clinic for Endocrinology, Diabetes and Diseases of Metabolism, Clinical Center of Vojvodina, Novi Sad, Serbia; 2Medical Faculty, University Novi Sad, Novi Sad, Serbia; 3Emergency Center, Clinical Center of Vojvodina, Novi Sad, Serbia.


Introduction and aim: Continuous subcutaneous insulin infusion via insulin pump is the most efficient way of imitating physiological insulin secretion, and it also provides better management of diabetes, lower rate of hypoglicemic episodes, better quality of life and prevention of long-term complications of diabetes mellitus. Aim of the research was to determine effects of subcutaneous insulin infusion therapy on parameters of glycoregulation during the two years trial.

Material and methods: Research was conducted at Clinic for endocrinology, diabetes and diseases of metabolism, Clinical center of Vojvodina, where 80 patients were treated this way during period of time from 2007 to 2015. There are complete results assembled for 60 patients with type I diabetes, from that 45 women, average age 31.67+8.03 and 15 men average age 26.06+8.25 years. In all subjects following parameters were monitored: sex, age, medical indications for this kind of therapy, complications of therapy, HbA1c in the moment of insulin pump application, after 6 months, 1 and 2 years of therapy.

Results: After starting with insulin pump therapy, better glycoregulation was notified, through statistically significant decrease in HbA1c rates after 6, 12 and 24 months. The biggest decrease in HbA1c rate was in those patients who had poorly regulated diabetes with HbA1c >10% in the moment of insulin pump application (usually former pediatric patients).

Conclusion: There is significant decrease in HbA1c rate after application of the insulin pump, and it is also confirmed that the biggest reduction in HbA1c rate (2–3%) was in those patients who had the worst glycoregulation (HbA1c >10%). Reduction of HbA1c did not result in higher rates of hypoglicemic episodes, while ketoacidosis was developed in two patients.

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