ECE2016 Eposter Presentations Obesity (69 abstracts)
Relationship between the severity of obstructive sleep apnoea (OSA), low-grade-inflammation (LGI) and Heme Oxygenase 1 (HO1) in morbidly obese (MO) patients, before and after bariatric surgery (BS)
Raquel Tirado 1 , María José Masdeu 2 , Laura Vigil 2 , Pere Rebassa 3 , Alexis Luna 3 , Sandra Montmany 3 , María Villaplana 1 , Belen Pons 1 , Mercedes Rigla 1 & Assumpta Caixàs 1
1Endocrinology and Nutrition Department, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí- UAB Universitat Autònoma de Barcelona, Campus d’Excel lència Internacio, Sabadell, Spain; 2Pneumology Department, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí- UAB Universitat Autònoma de Barcelona, Campus d’Excel lència Internacional 08193 Bellate, Sabadell, Spain; 3Surgery Department, Hospital de Sabadell, Corporació Sanitària Parc Taulí, Institut Universitari Parc Taulí- UAB Universitat Autònoma de Barelona, Campus d’Excel lència Internacional 08193 Bellaterra, Sabadell, Spain.
Introduction: HO1 is a new adipokine with a protective role against cellular stress and hypoxia1. MO presents with high low grade inflammation (LGI)2 and high circulating levels or adipose tissue expression of HO13. The effect of bariatric surgery on HO1 and its relationship with OSA and LGI has not yet been studied.
Methods: We studied 66 MO patients before and 1 year after BS. All of them presented OSA without Continuous Positive Airway Pressure (CPAP) treatment (20 mild, 16 moderate and 30 sever). OSA diagnosis was given after an overnight conventional polisomnography (CE-Series Compumedics, Victoria, Australia). Sleeve gastrectomy or Roux-en-Y gastric bypass were performed according to the local protocol. HO1 (Elisa Kit bioNova científica, s.l.Madrid) and LGI (TNFα, IL6, IL1β, PCR and adiponectin) were measured (Milliplex Catalog, Merck Millipore, Madrid), before and after bariatric surgery. BMI, waist circumference, % body fat by bioelectrical impedance (TANITA) and HOMA insulin resistance index were also assessed. For statistical analysis SPSS-PC-plus version 19 was used.
Results: Plasma HO1 did not differ between OSA groups. After surgery, HO1 levels decreased significantly (7.11±2.99 vs 6.59±2.47 ng/mL, P<0.01, before vs after), however, this effect was only observed in those patients who had sever OSA (7.64±3.78 vs 6.88±2.88 ng/mL, P=0.02, before vs after). The decrease in HO1 levels correlated with HOMA improvement (r=0.257, P=0.028) but not with the improvement of the other adipokines.
Conclusion: Improvement of plasma HO1 in MO patients after bariatric surgery is related to the severity of OSA and the degree of insulin resistance but not to LGI.
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Endocrine Abstracts
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