ECE2016 Oral Communications Diabetes prediction & complications (5 abstracts)
Improvement in diabetic neuropathy after metabolic surgery a comprehensive electrophysiological follow up study
Eylem Cagiltay 1 , Alper Celik 2 , Nurten Adatepe Uzun 3 , Riza Sonkaya 4 , Surendra Ugale 5 , Ayca Kayadibi 2 , Gülsüm Zengin 2 , Deniz Büyükbozkirli 2 , Turgut Adatepe 6 & Mustafa Ertas 7
1Department of Endocrinology, GATA Haydarpasa Training and Research Hospital, Istanbul, Turkey; 2Metabolic Surgery Clinic, Istanbul, Turkey; 3Department of Neurology, Istanbul University Cerrahpasa Medical Faculty, Istanbul, Turkey; 4Department of Neurology, GATA Haydarpasa Training and Research Hospital, Istanbul, Turkey; 5Kirloskar Hospital, Bariatric & Metabolic Surgery Clinic, Hyderabad, India; 6Istanbul Education and Training Hospital, Outpatient Clinic, Electromyography Laboratory, Istanbul, Turkey; 7Consultant Neurologist at Private Office, Istanbul, Turkey.
Aim: In the present study, we aimed to analyze the incidence of diabetic neuropathy (DN) via electrophysiological testing of type 2 diabetes mellitus (T2DM) patients scheduled for laparoscopic diverted sleeve gastrectomy with ileal transposition (DSIT). At a mean of 8 months after surgery, the electrophysiological tests were repeated and differences in electrophysiological parameters were evaluated to investigate the effects of the operation on outcomes related to diabetic neuropathy.
Methods: This cross sectional, non-blinded, prospective, pilot study included 55 severely diabetic non-responders, who fail to achieve adequate glycemic control despite appropriate medical treatment. Autonomic tests including motor and sensory nerve conduction studies (NCS), sympathetic skin response (SSR) and R-R interval analysis of patients scheduled for metabolic surgical treatments were performed pre- and postoperatively. The differences in metabolic and electrophysiological parameters were also analyzed. SPSS 15.0 for windows was used for statistical analysis. χ2 test, a non-parametric test, was used to analysis the difference in the data obtained from the all groups.
Results: Patients had mean diabetes duration of 13.4±7 years. Preoperative values of mean HbA1c, body weight and Body Mass Index (BMI) were 9.6±2%, 94.0±14.7 kg and 34.0±5.1 kg/m2 and decreased to 6.6±1%, 71.7±13.3 kg and 26.1±3.5 kg/m2 postoperatively (P<0.001, each). Preoperative NCS evaluation revealed presence of polyneuropathy in 27 (49%) individuals; however, postoperative NCS measures showed decreased distal conduction time in 61%, increased response amplitudes in 40% and increased conduction velocity in 57% of patients for motor nerves. As for sensory nerves, decreased distal conduction time was found in 55% and increased response amplitudes in 57% of patients. In addition, significant improvements were observed in the of SSR and R-R interval analysis postoperatively.
Conclusion: Beyond the improvements in metabolic parameters and BMI in our diabetic patients who underwent DSIT, we also observed improved NCS results. Improvement in NCS variables may be interpreted as a result of better glycemic control.
Volume 41
Article tools
My recent searches
My recently viewed abstracts
Authors
Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
© Bioscientifica 2024 |
Privacy policy |
Cookie settings
BiosciAbstracts
Bioscientifica Abstracts is the gateway to a series of products that provide a permanent, citable record of abstracts for biomedical and life science conferences.
Find out more