Reach further, in an Open Access Journal Endocrinology, Diabetes & Metabolism Case Reports

ISSN 1470-3947 (print)
ISSN 1479-6848 (online)

Searchable abstracts of presentations at key conferences in endocrinology

Published by BioScientifica
Endocrine Abstracts (2016) 44 P142 
| DOI:10.1530/endoabs.44.P142
|

Hypopituitarism is associated with decreased oxytocin concentrations and reduced empathic ability

Katie Daughters1, Antony Manstead1 & Aled Rees2

Author affiliations

Background: Cranial diabetes insipidus (CDI) is characterised by arginine vasopressin (AVP) deficiency. Oxytocin (OT) is structurally related to AVP and is synthesised in the same hypothalamic nuclei, but a clinical syndrome of OT deficiency is not currently recognised. Psychological research has demonstrated that OT influences social and emotional behaviours, particularly empathic behaviour.

Aim: We hypothesised that patients with acquired CDI and anterior hypopituitarism would display OT deficiency, and consequently perform worse on empathy-related tasks, compared to age-matched clinical control (CC – isolated anterior hypopituitarism) and healthy control (HC) groups.

Method: Fifty-six participants (Age 46.54±16.30 years; CDI: n=20, 8 males; CC: n=15, 6 males; HC: n=20, 7 males) provided two saliva samples (pre- and post-empathy tasks) which were analysed for OT using an ELISA method, and undertook two empathy tasks: the Reading the Mind in the Eyes Task (RMET) and the Facial Expression Recognition (FER) task.

Results: CDI patients (mean OT =86.1 pg/ml, S.E.=15.9) and CC patients (mean OT =86.6 pg/ml, S.E.=18.4) had lower OT concentrations compared to HC participants (mean OT =131.5 pg/ml, S.E.=15.9), but this did not quite reach significance (P=0.084). CDI and CC patients performed significantly worse on the RMET compared to HC participants (P=0.007). Regression analyses revealed that patients’ OT response during the study significantly predicted their RMET performance (P=0.025). CDI and CC patients also performed significantly worse compared to HC participants at identifying high intensity facial expressions (P=0.004).

Conclusions: Hypopituitarism may be associated with reduced OT concentrations and impaired empathic ability. Whilst further studies are needed to replicate these findings, our data suggest that OT replacement may offer a therapeutic approach to improve psychological well-being in patients with hypopituitarism.

This Issue/Conference

Article tools

My recent searches

Search Endocrine Abstracts for...

Search Google Scholar for...