ECE2017 Eposter Presentations: Reproductive Endocrinology Female Reproduction (62 abstracts)
Biochemical and clinical characteristics of polysystic ovarian syndrome (PCOS) in women with and without type 1 diabetes (TID)
Anjuli Gunness 1 , Agnieska Pazderska 1 , Mohamed Ahmed 1 , Niamh Phelan 1 , Gerard Boran 1 , AE Taylor 2 , MW O’Reilly 2 , Wiebke Arlt 2 , Kevin Moore 1 , Lucy-Ann Behan 1 , Mark Sherlock 1 & James Gibney 1
1Department of Endocrinology and Clinical Chemistry, Adelaide and Meath Hospital, Tallaght, Dublin 24, Ireland; 2Institute of Metabolism and Systems Research (IMSR), University of Birmingham, Edgbaston, Birmingham B15 2TT, UK.
Abstract: PCOS prevalence is reported to be increased in reproductive-age women with type-1 diabetes (T1DM) but measurement of androgens, crucial for diagnosis, has been with inaccurate immunoassays. No studies have been reported using liquid-chromatography-mass-spectrometry (LCMS). Reproductive-age T1DM women attending a single centre were evaluated for PCOS (NIH criteria). Women with T1DM and PCOS (T1/PCOS) were compared to T1DM women without hyperandrogenism (T1/no HA), and to two groups of non-diabetic women with PCOS – one group BMI-matched (PCOS-lean) and the other overweight (PCOS-overweight). 16 (18%) of T1DM women had PCOS. TIDM women with PCOS compared to the overall group were younger (26.5 vs 29) and had a lower BMI (23.4 vs 25.3). Compared to T1/no HA, testosterone (1.3 vs 0.8 nM, P=0.004) and androstenedione (7.1 vs 4.6 nM, P=0.0016) were elevated but no differences in DHEA-OX, DHEAS, SHBG or free testosterone was noted. They had an older age of menarche (13 vs 12.5 years, P=0.024), and were more likely (P=0.024) to have a positive family history of PCOS. There were no differences in androgen levels between T1/PCOS and PCOS-lean women, but both of these groups demonstrated greater androstenedione levels (7.1 vs 5.5 nM, P=0.0247) than PCOS-overweight women. In summary, PCOS is common in T1DM. Women with T1/PCOS are leaner than T1 women without PCOS but are more likely to have a family history of PCOS. They have a similar biochemical phenotype to lean women with PCOS but differ from overweight women with PCOS. The mechanisms underlying PCOS in T1DM and its clinical significance are unknown.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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