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Endocrine Abstracts (2018) 56 D4.1 | DOI: 10.1530/endoabs.56.D4.1

ECE2018 Debates AMH as the Primary Marker for Fertility (2 abstracts)

AMH is the primary marker for fertility (Pro)

Didier Dewailly


France.


In women, the anti-Mullerian hormone (AMH) is secreted by the granulosa cells of the growing follicles. Its assay is therefore strongly correlated with the antral follicular count and represents a reliable marker of the ovarian reserve. It also has the advantage of being very reproducible since it has little intra- and inter-cyclic variation. However, it seems to be a good quantitative reflection of the ovarian reserve but not qualitative. This drawback does not make this assay a good predictor of female fertility in the general population. On the other hand, the interest of AMH assay in the context of certain situations at risk or in the management of various pathologies is well established and it can become an indirect marker of female fertility. Indeed, the AMH assay is very useful in screening for situations at risk such as early ovarian insufficiency or polycystic ovary syndrome. Its interest is no longer to prove in assisted reproductive techniques where it is a valuable aid to the choice of techniques, ovarian stimulation protocols and dose of gonadotropins. The AMH assay is also very informative in the follow-up of cancer patients who have required the use of ovario-toxic products or who have undergone mutilating surgeries for the ovaries. In conclusion, although it can not be considered in isolation as a reliable predictor of the chance of pregnancy in women, the AMH assay is one of the essential measures in the management of female fertility.

Volume 56

20th European Congress of Endocrinology

Barcelona, Spain
19 May 2018 - 22 May 2018

European Society of Endocrinology 

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