ECE2018 ePoster Presentations Diabetes, Obesity and Metabolism (56 abstracts)
Sympathetic hyperactivity and sleep disorders: is Type 2 diabetes the link between these two situations?
Carolina López-Cano 1, , Liliana P Gutierrez-Carrasquilla 1 , Enric Sánchez 2 , Anna M Gaeta 3 , Raquel Marti 2 , Marta Hernández 1 , Gonzalo Cao 4 , Merce Ribelles 4 , Xavier Gómez 5 , Marta Sánchez 1 , Chadia Mizab 1 , Ferran Barbe 2, & Albert Lecube 1,
1Endocrinology Service, Hospital Universitari Arnau Vilanova, Lleida, Spain; 2Institut de Recerca Biomedica, Lleida, Spain; 3Pneumology Service, Hospital Universitari Arnau Vilanova, Lleida, Spain; 4Hospital Universitari Arnau Vilanova, Lleida, Spain; 5Medicine Department, Universitat de Lleida, Lleida, Spain.
Results: Main clinical, analytical and polygraphic data: 58.1±6.4 years, body mass index 32.4±5.4 kg/m2, 70.4% female, HbA1c 8.0±1.9%, AIH 27.4 events/hour (in the range of severe sleep apnea and hypoapnea index), and CT90% 32.9%. Nocturnal concentration of urine total metanephrines were higher than diurnal levels (226±12 vs 98±13 μg/l; P=0.085). In addition, its nocturnal concentration was significantly associated, in a positive way, with both the AIH and the CT90; however, this association disappeared when the diurnal concentration was evaluated. Furthermore, nocturnal concentration was also associated with a decrease in resting parasympathetic tone. In the multivariate analysis, the concentration of urine metanephrines at night independently predicted CT90 (P=0.016).
Conclusion: We suggest that the increased sympathetic activity previously described in patients with T2D is mediated through the deleterious effect of diabetes in nocturnal breathing. In addition, sympathetic activity is associated with disorders of autonomic tone at resting, suggesting a new pathological pathway between T2D and cardiovascular risk.
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Endocrine Abstracts
ISSN 1470-3947 (print) | ISSN 1479-6848 (online)
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