Endocrine Abstracts

Non-genetic animal models of diabetic nephropathy (DN) are most commonly reproduced by using streptozotocin (STZ) which preferentially gets into β-cells via GLUT2 transporters. However, STZ administration results in nephrotoxic effects as well, due to expression of GLUT2 by renal tubular epithelial cells. We hypothesized that nicotinamide (NA), which is considered to attenuate the severity of STZ-induced β-cell damage, could also prevent tubular alteration. Starting ...

Background: Videoassisted resection of the thyroid gland with unilateral nodular lesions of the thyroid gland, as compared to the conventional method is a safe and effective method.Materials and methods: Patient M, a woman 30 years old, BMI 30.37. Admitted with complaints of discomfort and a feeling of constriction in the neck, mild shortness of breath on exertion. The cervical lymph nodes were not enlarged. According to the USI are found nodes in the ri...

Background: Minimally invasive surgery in short time has been widely used in many fields of medicine and endocrinology not an exception. Having a number of advantages, such as small traumatic intervention, as well as cosmetic effect.Materials and methods: Selective embolization thyroid artery (SETA), we used as an independent method of treatment Graves’ disease (GD). Following this procedure the treatment of 17 patients received for the period from ...

Introduction: Prevention of surgical complications in patients with severe forms of Graves’ disease is still not completely solved problem. The purpose of research was improve the results of surgical treatment of patients with severe Graves’ disease.Materials and methods: In 2012 introduced a method of treatment of patients with Graves’ disease SETA as a preoperative preparation. Presented results of surgical treatment of 30 patients, with...

Introduction: The measurement of free thyroxine (FT4) and free 3,3′,5-triiodothyronine (FT3) in serum by equilibrium dialysis immunoassay methods may suffer from a lack of specificity, therefore measurement by LC/MS/MS has the potential to increase the accuracy of the results. Here we present a sensitive method, employing a simple ultrafiltration sample preparation.Description of methods: 400 uL of serum were processed for 90 minutes using a 3kDa c...

There is clear evidence in humans that stress during pregnancy has negative consequences on the foetus leading to greater susceptibility to disorders such as heart disease, diabetes type II and anxiety in adulthood. We aimed to assess whether stressors experienced by commercial pigs have a detrimental impact on piglet behavioural and neurophysiological development. Thirty-six primiparous sows were divided into control and two mixed groups that were stressed (social mixing) dur...

Background: Neuroendocrine tumours (NETs) arise from neuroendocrine cells, they are commonly found in the pancreas, small bowel and lung. They are a heterogeneous group of tumours capable of secreting a variety of hormones, therefore the spectrum of symptoms is broad. Treatment options for metastatic NETs include cytoreductive surgery, or interventional radiology procedures such as transarterial embolization (TAE). Aims: Previous studies have shown that ...

Disorders of sex development (DSD) are a collection of rare congenital conditions with diverse features and pathophysiology. Patients usually present at birth with atypical genitalia or with delayed puberty in adolescence. Biochemical and cytogenetic investigations may provide guidance on the underlying cause, however molecular genetic analysis is usually required to provide a definitive diagnosis and allows for personalised management of the patient. The current diagnostic se...

Whole-body cortisol content was measured in oocyte, embryo and larvae of rainbow trout by extraction and RIA. The cortisol content of oocyte was 2.55±0.06 ng/ml that probably has a mathernal origin. After fertilization cortisol level decreased to 1.84±0.07 ng/ml, then reached to the lowest level (0.30±0.06 ng/ml) by day 10 where it remained unchanged until eyed stage on day 18. After that cortisol increased at hatching to 0.60±0.06 ng/ml, suggested that cor...

Case history: A 40-year-old, primaparous woman was referred at 24 weeks’ gestation to Obstetric Medicine for review of abnormal thyroid function tests (TFTs).Investigations: One year prior to pregnancy, TFTs included a thyroid stimulating hormone (TSH) level of 0.95 mU/l (local non-pregnant reference range 0.3–4.2 mU/l) and a free thyroxine level (fT4) of 7.3 mU/l (local non-pregnant reference range 9.0–23.0 mU/l). At 18 weeks’ gestat...