Endocrine Abstracts

Background: Hyperthyroidism has been associated with increased all-cause mortality. Whether the underlying cause of hyperthyroidism influences this association is unclear. Our hypothesis was that Graves’ disease (GD) and toxic nodular goiter (TNG) differ with respect to mortality risk and cause of death.Methods: An observational cohort study, using record-linkage data from nation-wide Danish health registers. 1.291 and 861 subjects with GD and TNG, ...

Background: Hypothyroidism has been linked with an increased risk of morbidity such as cardiovascular disease and diabetes mellitus. However, it is unknown whether the burden of morbidity is present before or after the diagnosis of hypothyroidism.Aim: Evaluate the temporality and type of morbidity in hypothyroid patients.Methods: Observational cohort study. Based on record-linking between official Danish health registers 2822 subje...

Introduction: Overt hyperthyroidism (OH) is associated with potentially lethal conditions such as atrial fibrillation, pulmonary embolism, stroke and coagulopathy. OH has also been connected with an increased mortality. However, this could be the result of common genetic and environmental factors affecting both OH and mortality.Objective: To investigate if OH is associated with an increased mortality and to what degree the relation might be explained fro...

Background: Overt hypothyroidism (OH) has repeatedly been associated with a number of potential lethal conditions. However, it is still debated whether OH is linked with increased mortality. Moreover, a link between OH and mortality could be the result of common genetic and environmental factors affecting both OH and mortality. Investigating twin pairs discordant for OH can minimize this potential confounding. Our objective was to investigate, at a nationwide level, whether OH...

Introduction: Subclinical hypothyroidism (subhypo) is linked to gestational hypertension (gestHT) and preeclampsia. Thyroid hormones have major influence on mitochondrial activity and the mitochondrial membrane potential (MMP) reflects the functional status of the mitochondria.Aim: The aim was to estimate whether mitochondrial function is impaired in pregnant women with or without gestHT.Methods: We included third trimester pregnan...

Background: Language development during early childhood is considered an important marker of fetal neurodevelopment. Prenatal cortisol exposure plays a critical role in maturation of the fetal brain; however, the effect on offspring language development needs further investigation. This study aimed to evaluate the association between maternal 3rd trimester cortisol and early longitudinal offspring language development and to test whether there was sex differences in...

Introduction: Patients who do not develop overt hypothyroidism after hemithyroidectomy for benign euthyroid goiter have permanently increased serum levels of TSH and decreased levels of thyroid hormones within the reference ranges. Thyroid hormones are major regulators of mitochondrial function, and the mitochondrial membrane potential (MMP) can be measured by flow cytometry analysis of living cells as the fluorescence intensity of stained peripheral mononuclear blood cells (M...

Introduction: Maternal thyroid function in early pregnancy is crucial for fetal neural development. Early offspring language acquisition is an important indicator of fetal neural development and a predictor of future cognitive development. We aimed to investigate how the mother’s thyroid function and the presence of thyroid autoimmunity in early pregnancy are associated with offspring’s language acquisition at the age of 12-37 months.Methods: T...

It is now well demonstrated that, in the human adrenal gland, aldosterone and cortisol productions are stimulated by autocrine/paracrine factors, like serotonin (5-HT) and arginine vasopressin (AVP). Several data indicate that these signals may also be involved in the regulation of corticosteroidogenesis in adrenocortical hyperplasias and tumors. 5-HT is detected in clusters of steroidogenic cells in aldosterone-producing adrenocortical adenomas (APAs), and in both ACTH-indepe...

We present a case of fludrocortisone-induced hypomagnesaemia in a 27-year old female with Autoimmune Polyglandular Syndrome Type1, manifesting as adrenal insufficiency, hypothyroidism and hypoparathyroidism. Her medications were; Alfalcidol 4 mcg; Levothyroxine 100 mcg; Hydrocortisone 20 mg bid; Fludrocortisone 200 mcg mane and 100 mcg nocte. The nocturnal dose of fludrocortisone was started 4 months prior to her presentation. She presented with a history of abdominal pain and...