Endocrine Abstracts

Introduction: Primary hyperparathyroidism (PHPT) is the most common cause of hypercalcemia, most cases with parathyroid adenoma as the underlying pathology. However, when blood and urine calcium levels and PTH are higher than normal in PHPT, t’s important to suspect an ectopic PTH secretion or a parathyroid carcinoma. Intrathyroidal parathyroid cysts are extremely rare cause of severe PHPT.Clinical case: A 36-year-old male presented with dizziness ...

IntroductionSemaglutide is a glucagon-like peptide-1 receptor agonist which has shown important benefits in patients with type 2 diabetes mellitus (T2DM) in randomized clinical trials. Its commercialization in Spain began in May of 2019. The main purpose of this study was to analyze the effectiveness of this drug into routine clinical practice in patients with T2DM with a body-mass index above 30 kg/m2.Matherial and meth...

IntroductionThe pandemic has altered the day-to-day running of hospitals and most of the material and human resources have been made available for COVID-19 care. So have the residents in Endocrinology and Nutrition (MIR), who have been working on the front line, and this has led to alterations in their training programme. In addition, this unexpected and stressful work situation has had psychological consequences. The Spanish Society of Endocrinology and...

Among its numerous comorbidities, obesity is often linked to central hypogonadism in men, i.e., low circulating levels of gonadotropins and testosterone. While this condition of obesity-induced hypogonadism (OIH) is frequently neglected, it has been suggested to contribute to the metabolic complications of male obesity. However, the mechanisms of OIH, and even its actual role in the metabolic alterations of obesity remain ill defined. Our recent data suggest that OIH is bound ...

A 36-year-old woman in follow-up due to early ovarian failure of idiopathic origin. No family history of interest. History of menarche at 12 years of age with regular menses until 18 years of age, when it begins with amenorrheic spells lasting up to 8 months. Laboratory tests revealed hypergonadotropic hypogonadism with negative ovarian autoantibodies, normal karyotype, and gynecological ultrasound showing a normal-looking uterus with slight bilateral ovarian atrophy. Negative...

Introduction: Transsexuality is defined as discordance between one’s assigned sex at birth and that individual’s gender identity. Hormonal, anatomical, legal and psychosocial adaptations are present in most cases. Following recent changes to the Spanish legal framework, modifications have instaured to the model of attention for transsexual people in Andalusia. The aim of this study was to evaluate healthcare demand evolution in Trans People Attention Unit of Puerta...

Cyclophosphamide is an alkylating agent used in the treatment of malignant and autoimmune diseases. Severe hyponatraemia is a serious electrolyte disorder with life threatening neurological sequelae. We report a case of recurrent severe, symptomatic hyponatraemia that developed in a 61 year old female with systemic vasculitis and Sjogrens syndrome following low-dose cyclophosphamide.Case report: A 61 year old lady, with ANA positive systemic vasculitis p...

Zoledronic acid (ZA) treatment increases bone mineral density (BMD), decreases bone turnover markers and reduces the risk of fractures in patients with osteoporosis (1).Objective: Observe and quantify the changes in BMD and bone turnover markers in postmenopausal osteoporosis (PO) patients treated annually with zoledronic acid 5 mg intravenously.Material and Methods: Medical records (MR) of PO patients whom received ZA from 2007 to...

Bariatric surgery (BS) improves quality of life and health due to the beneficial effect on the metabolism at multiple levels. Specifically, its effectiveness in weight loss and the attenuation or resolution of comorbidities associated with obesity, means lower morbidity and mortality compared to other types of interventions. The objective is to analyze the evolution of obesity-related diseases after twelve months of follow-up.Methods: Retrospective study...

Pheochromocytoma (PCC) is a rare tumor that arises from the adrenal medulla, usually presents with headache, sweating and palpitations due to excessive catecholamine release. However, PCC may secrete neuropeptides, hormones and cytokines, such as interleukin-6 (IL-6)) resulting in unusual clinical manifestations. A 48-year-old woman with a previous history of type 1 neurofibromatosis (NF1) and hypertension was referred to discarded PCC. Laboratory tests revealed leukocytosis a...