Endocrine Abstracts

The ingestion of marine foods is a potential route of contamination by tributyltin (TBT), a biocide organotin used as an antifouling in boat paints. TBT causes a phenomenon known as imposex, that induces, for instance, the irreversible appearance of male sexual characteristics in gastropod females. In mammals, TBT also directly impairs the sexual development. In fact, it is known that TBT can affect women in reproductive age. Our aim was to study whether the maternal exposure ...

Tributyltin (TBT) is a biocide organotin compound widely used as an antifouling in boat paints. This substance is a factor of contamination to water and food, especially marine fish. As an endocrine disruptor, TBT can interact with hormonal pathways and can induce gonadal dysfunction and glycemic dyshomeostasis; however, the effects caused by maternal exposure to TBT are scarce. Here, we investigate maternal exposure to low dose of TBT, considered safe, during pregnancy and la...

Caffeine crosses the placenta and mammary barrier and can affect the offspring metabolism and endocrine system from heavy caffeine users. Here, we tested the impact of a safe dose of maternal caffeine (200-300 mg/day) on plasma hormone of offspring from both sexes at different ages (weaning, puberty and adulthood). For this, pregnant Wistar rats received caffeine (25mg/kg/day) by gavage or vehicle during gestation (GEST group), lactation (LACT group) or both periods (G+L group...

Brown tumor (BT) is a rare bony benign lesion caused by excess osteoclast activity and hemosiderin deposition because of uncontrolled primary or secondary hyperparathyroidism. 71-year-old man with no significant pathological history, twelve months before admission presented with growing mandibular brown tumor and bone pain in lower limbs. He was referred to Endocrinology unit. Physical examination found left facial paralysis, absence of horizontal branches and left jaw ascendi...

Background/aims: Caregivers play a crucial role in self-management of long-term conditions. The aim of this literature review was to explore the impact that Type 2 diabetes has on the caregivers’ quality of life (QoL) and its significance in integrated healthcare.Methods: A search was undertaken in CINAHL, MEDLINE, BNI and ASSIA using combinations of the following keywords limited to adults, humans and published in English in the last 10 years: 1: c...

Background: Testicular Adrenal Rest Tumors (TART) in patients with congenital adrenal hyperplasia due to 21-hydroxylase deficiency (21OHD) or 11-hydroxylase deficiency (11OHD) are benign lesions causing testicular damage and infertility. We hypothesize that high ACTH exposure due to poor hormonal control during early life is promoting development of TART later in life.Objective: This study aims to examine the relation between early CAH diagnosis and cons...

Introduction: Pituitary Insufficiency is life threatening condition, that can lead or manifest by any stressful situation (surgery, infections, intoxication and etc) Case report: A 70-year-old man diagnosed with Bladder Cancer had underwent surgery - Cystoplasty. The operation was performed without complications, but, after the intervention, the general condition of the patient sharply declined. There appeared strong general weakness, blurred consciousne...

Introduction: Whilst effective, targeted checkpoint inhibitor monoclonal antibodies are associated with immune-related adverse events including endocrinopathies. Increased licensed oncological indications for these agents raise the need for effective screening, monitoring and ongoing treatment of endocrinopathies. The aim of our study was to investigate potential predictive factors that may identify patients at risk of endocrinopathies....

Introduction: Whilst effective, targeted checkpoint inhibitor monoclonal antibodies are associated with immune-related adverse events including endocrinopathies. Increased licensed oncological indications for these agents raise the need for effective screening, monitoring and ongoing treatment of endocrinopathies. The aim of our study was to investigate potential predictive factors that may identify patients at risk of endocrinopathies....

Background: Immune checkpoint inhibitors (ICIs), approved in the UK for the treatment of increasingly numerous malignancies, are commonly associated with endocrine sequelae, some of which may be life threatening. Society for Endocrinology guidelines detail management protocols for acute endocrinopathies, however widely accepted standards for their routine detection are lacking. Hypophysitis, clinically and radiologically silent in many, is seen in up to 15% of patients on ICIs...