Endocrine Abstracts

Vitamin D (VD) deficiency (25 OHD < 50 nmol/l) is common is chronic liver disease at 64%–92% regardless of aetiology. The only guidelines for routine VD supplementation are for cholestatic (C) liver disease; a population considered being at high risk of low bone mineral density (BMD). BMD decreases further following orthotopic liver transplant (OLT). To assess VD intake in an at risk population, retrospective analysis of intake was performed in OLT patients with C liv...

Tom Armstrong will present evidence to support the role of surgical resection NET liver in the case based discussion detailed above....

Glucocorticoid (GC) excess, Cushing’s syndrome, is characterized by central obesity, proximal myopathy, insulin resistance and potentially type 2 diabetes mellitus. Current dogma dictates that GCs cause insulin resistance across all tissues. We have previously demonstrated that GCs cause insulin sensitization of human adipose tissue in vitro, whilst inducing insulin resistance in human skeletal muscle. No prior study has evaluated whether these observations transla...

Evidence-based clinical guidelines in Endocrinology attempt to improve and standardise patient care. There has been an expansion in guideline production although some of the heterogeneous methods used to assess the underlying evidence base may limit interpretation and implementation. Current and archived guidelines from The American Association of Clinical Endocrinologists (AACE), The Endocrine Society (ES), The American Thyroid Association, The British Thyroid Association and...

GnRH acts via Gq/11-coupled GPCRs on gonadotropes to control synthesis and secretion of LH and FSH. We use mathematical and statistical approaches as well as automated cell imaging to explore this system. In cells expressing ERK2–GFP and GnRH receptors, GnRH pulses cause rapid and transient nuclear translocation of ERK2–GFP, providing a live-cell readout for ERK activation1. A mathematical model trained against this data predicted greater sensitivity to re...

The management of patient care is to ensure that individuals are provided with appropriate support and representation during their cancer journey, from the point of diagnosis, throughout treatment and into survivorship. The Clinical Nurse Specialist (CNS) role has become pivotal in many specialities, providing aspects of care such as meeting information needs, holistic nurse led follow up, managing care and providing psychological and social interventions, including referral t...

Background: Neuroendocrine tumours (NETs) arise from neuroendocrine cells, they are commonly found in the pancreas, small bowel and lung. They are a heterogeneous group of tumours capable of secreting a variety of hormones, therefore the spectrum of symptoms is broad. Treatment options for metastatic NETs include cytoreductive surgery, or interventional radiology procedures such as transarterial embolization (TAE). Aims: Previous studies have shown that ...

Introduction: Not much has been reported about Idiopathic Postprandial syndrome, especially in Africa. Many cases are often wrongly diagnosed as reactive hypoglycemia. Idiopathic postprandial syndrome refers to signs and symptoms of hypoglycemia in the absence of low blood sugar occurring after meals and is of unknown cause. Clinical case: We report a case of Idiopathic Postprandial Syndrome in a 44-year old woman living in Nigeria. We present a 44-year-...

Traditionally, oestradiol measurement is performed by immunoassay. The sensitivity of these assays is not sufficiently sensitive for certain patient groups such as males, post-menopausal females and children. There is also a potential for interference from structurally related compounds or heterophilic antibodies. LC–MS/MS is an attractive alternative as it has increased sensitivity and specificity.We reviewed the requests for LC–MS/MS analysis...

We measured chromogranin A (CgA) and chromogranin B (CgB) in 36 patients, recently confirmed to have a midgut carcinoid tumour (MGC), prior to the commencement of octreotide treatment. Blood samples were taken before and after a bolus injection of 50 μg octreotide. There were 21 males, 15 females, age range 28–76 median 61 years.Basal CgA, expressed as times the upper limit of normal (ULN) ranged from 333.3 to 0.5 ULN. Basal CgB ranged from 33....