Endocrine Abstracts

Background: Fractalkine (CX3CL1) is known to convey its signals through a single G-protein coupled receptor (CX3CR1). It is characterized as a structurally unique chemokine with both membrane-bound and soluble forms. Fractalkine expression has been detected in activated or stressed endothelial, smooth muscle, skeletal muscle, macrophages, neurons, hepatocytes and adipocytes. Inflammation up regulates Fractalkine particularly in adipose tissue of obese individuals.<p class=...

Obesity is a major risk factor for chronic non communicable diseases and plays a central role in the insulin resistance or metabolic syndrome, which includes hyperinsulinemia, hypertension, hyperlipidemia, type 2 diabetes mellitus, and an increased risk of adult onset obesity and atherosclerotic cardiovascular disease (1). Insulin resistance is a state in which a given concentration of insulin produces a less than expected biological effect. The metabolic syndrome is a cluster...

Introduction: Therapeutic education (TE) on injection techniques and zooning is a key step for any insulin-treated patient. Our study’s objective was to evaluate the role of ET and the number of sessions required to prevent lipodystrophies (LD).Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followed in our unit between February 2015 and June 2017. Patients responded to a...

Introduction: A good injection technique is crucial to ensure that insulin is properly administered into the subcutaneous tissue and then released at the right time, to avoid some common complications such as lipodystrophies (LD). The objective of our study is to evaluate injection techniques in Moroccan diabetic patients.Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followe...

Introduction: Changing needles and syringes when injecting insulin is often included in recommendations on injection techniques and in education sessions. The objective of our study was to evaluate the rate of insulin needle reuse and its consequences.Materials and methods: We conducted a prospective study including any diabetic insulin-treated patient for more than 6 months, followed up at the service between February 2015 and June 2017. Patients respon...

Introduction: Maturity Onset Diabetes of the Young (MODY) is a monogenic form of non-insulin-dependent diabetes that classically presents in a lean individual with non ketotic hyperglycaemia and an autosomal dominant inheritance pattern. The diagnosis remains a challenge and may be made by careful clinical evaluation, but exact sub-typing is possible only by genetic analysis.Materials and methods: This is a prospective data analysis in the diabetology-en...

A 44-year-old women without personal or familial pathological history, presented 8 months before her admission a paroxystic symptomatology made of palpitations, headache and profus sweat associated with major abdominal pain, evolving in a context of alteration of the general state. Clinical examination objectified high blood pressure and tachycardia. Laboratory testing confirmed the diagnosis of pheochromocytoma. A computed tomography of the abdomen revealed a bilateral adrena...

Introduction: Association between primary hyperparathyroidism and nodular thyroid disease is well recognized, this is mainly due to the high prevalence of this disease. However, association between thyroid carcinoma and primary hyperparathyroidism is less common.Observation: Fifty-two years old patient with a history of renal colic and upper limb spontaneous fracture was followed for multinodular goiter evolving for 20 y...

We present the case of a 50-year-old woman who presented with 12 months of amenorrhea associated with signs of virilisation. Investigations revealed markedly raised serum concentrations of testosterone (9 nmol/l), whereas sex hormone binding globulin, random cortisol, androstenedione, 17-hydroxyprogesterone and dehydroepiandrosterone sulphate concentrations were all within the normal range. Computed tomography scan of the pelvis and abdomen showed a slightly bulky right ovary,...

Introduction: The use of Inferior Petrosal Sinus Sampling (IPSS) to differentiate between central and ectopic ACTH dependent Cushing’s, although requires expertise, is widely available. The value of adding prolactin measurement to that of ACTH to improve IPSS diagnostic accuracy remains controversial. We evaluated the impact of adding prolactin measurement to IPSS procedures at a large academic center.Methods: Leftover samples from patients who were...