Endocrine Abstracts

Introduction: Hyperprolactinemia has been associated with dyslipidaemia, hypercoagulability, impaired endothelial function and decreased insulin sensitivity. Recent data show that prolactin hormone (PRL) could contribute to atherogenesis. The aim of our study was to investigate the relationship between MPV and PRL, androgen hormones, lipid profiles in premenopausal prolactinoma patients, who did not have insulin resistance (IR).Methods: Thirty-nine newly...

Introduction: Helicobacter pylori (HP) infection is the most significant cause of gastritis and related morbidities. Radioactive iodine treatment (RAIT) is an important option in the treatment of hyperthyroidism. In addition to thyroid gland, RAI accumulates in stomach in significant amounts. In our study, we planned to investigate whether RAIT has an effect on carbon-14-urea breath test (UBT) in patients with hyperthyroidism.Materials-method: The...

Introduction: It is commonly known that hearing and balance functions are affected in thyroid function disorders. In literature, there are very few studies demonstrating that hearing may be affected due to autoimmunity in euthyroid Hashimoto’s thyroiditis (HT) independent from thyroid functions. In addition, hearing disorders have also been reported in other autoimmune diseases. For this reason, we investigated the functions of the peripheral and central sections of audit...

Introduction: Hypogonadism have major affect on urogenital system also have several affect on other systems like cardiovascular and skeletal systems. There are very few study conducted on markers of atherosclerosis such as flow mediated dilatation (%FMD), carotis intima-media thickness(CIMT) and adipocytokine levels in idiopatic hypogonadotropic hypogonadal(IHH) males. The aim of this study was to evaluate this atherosclerotic risk factors in adult IHH male.<p class="abste...

ApoB isoforms are components of the chylomicron, and of the atherogenic LDL and Lp(a) particles. Ex26 is exceptionally long at 7.57kb as most exons are <500bp. Ex26 is also the site of RNA editing, which generates the ApoB48 isoform instead of ApoB100. The first 3kb of ex26 contains 15 sequences matching the splice site consensus, which could be used in splicing, but are not. Splice sites matching the consensus but which are not used are called pseudosites. How the spliceos...

Background: In the presence of specific symptoms and signs, Cushing’s syndrome (CS) may be easily recognised. On the other hand, in overweight and obese patients without typical features of CS, diagnosis may be omitted. Our aim was to evaluate the prevalence of CS among overweight and obese patients.Methods: We enrolled 264 overweight and obese patients who has not overt CS clinical features between January 2012 and December 2014 at Ankara Numune Ed...

Association between idiopathic hypogonadotropic hypogonadism (IHH) and atherosclerotic disease in young males remains unclear. The present study aimed to determine the effect of improving the testosterone level on cardiovasculary (CV) risk markers in young males with IHH.Materials and methods: The study included 19 non-obese males with IHH and 17 healthy controls. The patients were treated with hCG therapy (n=8) or testosterone replacement (...

Introduction: Multifocal sclerosing thyroiditis (MST) is a recently proposed histopathological diagnosis for thyroidectomy specimens that have ≥1 radial scar-like foci. Despite the inclusion of the term thyroiditis, MST is not related to other well-known types of thyroiditis and does not have a specific clinical presentation.Case report: A 30-year-old female presented clinic due to thyrotoxicosis. She did not have any symptoms related to thyrotoxic...

Introduction: Gardner syndrome (GS) have very different extraintestinal manifestations such as include osteomas and thyroid cancers. Thyroid carcinomas associated with familial adenomatozis polyposis coli (FAP), are typically bilateral and multifocal. Our case presenting that GS included Graves’ disease (GD) and aggressive varyant of PTC.Case report: A 43-year-old men admitted to our out patient clinic for thyrotoxicosis investigation. He was compla...

Background: Mutations in succinate dehydrogense-B (SDH-B) or von Hippel Lindau (VHL) genes can result in chromaffin tumours.Objective: To compare the clinical phenotypes of subjects developing chromaffin tumours as a result of SDH-B or VHL mutations.Subjects: Thirty-one subjects with chromaffin tumours. Sixteen subjects had SDH-B gene mutations and 15 subjects had a diagnosis of VHL.<p ...