Endocrine Abstracts

ApoB isoforms are components of the chylomicron, and of the atherogenic LDL and Lp(a) particles. Ex26 is exceptionally long at 7.57kb as most exons are <500bp. Ex26 is also the site of RNA editing, which generates the ApoB48 isoform instead of ApoB100. The first 3kb of ex26 contains 15 sequences matching the splice site consensus, which could be used in splicing, but are not. Splice sites matching the consensus but which are not used are called pseudosites. How the spliceos...

Diabetes, one of the most commonly seen metabolic disorders, is affecting a major area of population in many developing as well as most of the developed countries and is becoming an alarming concern for the rising cost of the healthcare system. Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is less recognized and under diagnosed type of diabetes which appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age a...

The aim of study was to recurrently follow quality of life in type 1 diabetes patients after multiple educations and counseling. Ninty six patients of the age group of “between” 10 to 25 were initially examined in 2004 and Eighty eight patients of them were reexamined in 2006 after multiple counseling with diabetologist and trained diabetes educator at dia care, Ahmedabad, Gujarat, India. Quality of life was defined as perceived well being and life satisfaction, glob...

The study was aimed to compare the outcome of pregnancies in women with type 1 diabetes treated with continuous subcutaneous insulin infusion pump (CSII) or multiple insulin injections (MDI). Total 14 patients were treated with insulin pump and 20 patients were treated with multiple injections; were mainly investigated for HbA1c, incidence of hypoglycemia, fetal outcome, rates of pregnancy induced hypertension and cesarean section. HbA1c with insulin pump was significantly bet...

Background: Mutations in succinate dehydrogense-B (SDH-B) or von Hippel Lindau (VHL) genes can result in chromaffin tumours.Objective: To compare the clinical phenotypes of subjects developing chromaffin tumours as a result of SDH-B or VHL mutations.Subjects: Thirty-one subjects with chromaffin tumours. Sixteen subjects had SDH-B gene mutations and 15 subjects had a diagnosis of VHL.<p ...

Mitogenic signaling by receptor tyrosine kinases that involve increased activity of phosphatidylinositol-3-kinase (PI3K) and over-activation of protein kinase B (PKB/Akt) triggers a cascade of responses that drive tumour progression in a variety of human cancers. Some of these events have been associated with diminished expression of the cell cycle inhibitor p27 through inhibition of a Forkhead transcription factor (FKHR-L1) by Akt, while some others have recently been reporte...

B-type natriuretic peptide (BNP) is a hormone secreted from the heart in response to volume load and serves clinically as a reliable biomarker in the diagnosis of cardiac dysfunction and heart failure. As patients with heart failure present an increased risk for developing diabetes, we aimed to investigate the role of BNP on parameters of glucose metabolism in a placebo-controlled crossover study performed in 10 healthy volunteers (25±1 years; BMI 23±1 kg/m2</su...

Introduction: Type 2 Diabetes Mellitus (T2DM) is the most common type of diabetes in adults, People with Diabetes usually have depression which is many times undiagnosed. Significant data suggest that depression in the context of diabetes is related to a variety of negative outcomes, including poor treatment adherence, decreased quality of life, deranged blood sugar values and HbA1c levels, and increased health costs.Method: 40 patients who consented to ...

Background: Type 2 diabetes mellitus (T2DM) is a chronic medical condition characterised by persistently high blood glucose levels. T2DM risk factors include obesity or being overweight, a high BMI, genetics, and certain medical conditions. Medicine adherence is very important for the management of T2DM and if it is not well controlled by lifestyle modification or DM regulatory medications, it can lead to complications. The goal of this study is to identify the factors that co...

Background: Nutritional interventions are required for effective management of diabetes Mellitus. Dietary recommendations act as amajor intervention for treatment of D Mand obesity. It is recommended that the diet should be individually adapted to personal choices and metabolic goals. With advent of technology newer monitoring tools like continuous glucose monitoring systems (CGM) are now finding their way into Diabetes management and nutrition therapy. The ambulatory glucose ...