Endocrine Abstracts

ACTH deficiency is a rare cause of secondary adrenocortical insufficiency and frequently associated autoimmune-mediated hypothyroidism, but there has been no report associated autoimmune-mediated hepatitis. We present a 36-year-old female with generalized weakness, malaise, hypersomnolence. Investigations showed low albumin, prolonged PT, elevated bilirubin level and abdominal ultrasonography and CT revealed liver cirrhosis with ascites. Though serologic test for hapatopathy w...

Background: Patients who require levothyroxine (LT4) supplementation after total thyroidectomy often have difficulty achieving target TSH levels. Several studies have attempted to develop a dosing schedule considering different factors such as age, gender, weight, or body mass index (BMI) as potential determinants of the correct dose of LT4. The objective of this study is to determine if a scheme that uses the percentage of body fat (%BF) measured by CUN-BAE is more accurate t...

The cytosolic calcium concentration is regulated by calcium-processing proteins such as transient receptor potential cation channel subfamily V member 5 (TRPV5), TRPV6, sodium-calcium exchanger 1 (NCX1) and plasma membrane Ca2+ ATPase 1 (PMCA1). Those calcium-processing proteins are important for physiological functions in the brain. The effects of steroid hormones on calcium-processing protein expressions in the brains are undescribed. Thus, the effects of steroid ...

Background: Extrathyroidal extension (ETE) is an important factor to determine treatment strategy of thyroid cancer. The purpose of this study was to present a new method to predict ETE in papillary thyroid carcinoma (PTC).Methods: This study included 1,481 patients with PTCs. The ETE was classified into minimal and gross ETE. Using an protrusion angle of the tumor on sonography (PATOS) system, we calculated optimal cut-off values to predict ETE accordin...

Vasoactive intestinal peptide (VIP) and pituitary adenylate cyclase-activating peptide (PACAP) are important neuropeptides that are structurally related. They have been found to exert many physiological and pathophysiological effects through the activation of three specific receptors: PAC1R, VPAC1R, and VPAC2R. In tetrapods, PACAP and VIP are potent agonists to VPAC2R. In teleosts, we have previously identified a PHIR in goldfish which shares high level of sequence similarity ...

Introduction: Thyroid function tests (thyroid hormones and thyreotropin) are frequently used by physicians all over the world. The interpretation is usually quite simple and straight-forward, however sometimes there is a strange discrepancy between the laboratory findings and clinical presentation. There are several potential explanations to this discrepancy and interference in laboratory assay may be one of them.Observation: We present a case of a 73-ye...

Objective: Impaired cognitive function has been demonstrated in adults with GH deficiency (GHD) and acromegaly by using different neuropsychological tests. P300 ERP application is a well established neurophysiological approach in the assessment of cognitive function. However the comparison of the P300 ERPs between GHD and GH excess have not been done yet. The present study was designed to investigate the effects of GHD and acromegaly on cognitive function by using P300 ERPs.</...

Introduction: Thyroid isthmus has lack of normal parenchyma, and it connects both of thyroid lobes with lymphatic drainage. It is known that isthmic papillary thyroid cancer (PTC) presents frequent extrathyroidal extensions (ETE), multifocality and lymph node involvement. Therefore, many surgeons prefer total thyroidectomy and central compartment neck dissection (CCND) for the radical treatment of PTC located in thyroid isthmus. The purpose of this study is to figure out the c...

Tetrabromobisphenol A (TBBPA) is a brominated flame retardant and is widely used in electronic goods, plastics and furniture. TBBPA is frequently detected in water, soil, organisms and even in human breast milk. It is accessible to both the developing fetus and the nursing pups following maternal exposure. Though some regulatory agencies have asserted that consumer exposures to TBBPA are unlikely to have adverse implications for human health, the safety of TBBPA has been quest...

Mitochondria play an important role in generating energy, and they are essential to cell survival. Mitochondria have varieties of functions, such as regulating intracellular calcium concentration and signal transduction, controlling hormone synthesis, inflammatory responses, and free radicals. In particular this research is interested in the mitochondria in kidney tubular cell. Since mitochondria in tubular cells play an important role in supplying energy, removal of waste and...