Endocrine Abstracts

Relation of dehydroepiandrosterone sulphate (DHEAS) concentration and adrenal tumors (AT) has never been investigated systematically. After promising Terzolo group (1995, 1996, 2000) investigations, there was made a recommendation in the last clinical guidelines for adrenal incidentaloma (2016) to assess concentration of DHEAS in special clinical situations. Here we present the first systemic study of DHEAS in adrenal tumors.The aim was to analyse the cl...

A 38–year-old female was diagnosed with right breast cancer cT2mN0M0G3 with positive BRCA+ gene mutation. The patient was treated with neoadjuvant chemotherapy plus one dose immune checkpoint inhibitor Pembrolizumab following bilateral radical mastectomy, extirpation of the right sentinel lymph nodes and bilateral reconstruction with an implant. Approximately one month after using Pembrolizumab the patient noticed extreme fatigue, decreased blood pressure, accelerated pul...

Background: The incidence and mortality rates of thyroid cancer (TC) vary across nations for reasons such as registry accuracy, diagnostic and management practices, care quality, and standardization methods. Risk factors for TC include genetic abnormalities, iodine intake, TSH levels, autoimmune thyroid disease, gender, lifestyle, and environmental pollutants. In 2005, a mandatory salt iodization program was implemented in Lithuania. This study aims to analyse TC incidence and...

A 60–year-old male and 24–year-old female presented to the endocrinologist with hyperthyroidism of unknown cause. A 60-year-old male was admitted to the Department of Endocrinology with fatigue, dyspnoea, increased sweating, and anxiety. Hyperthyroidism was diagnosed with TSH < 0.0008 mIU/l [reference range: 0.3500 – 4.9400], FT4 – 4.03 ng/dl [reference range: 0.89 – 1.76] and FT3 – 12.96 [reference range: 2.3-4.2]. The patient had a...

Introduction: As our population ages, more people are diagnosed with thyroid nodules (TN). The prevalence of TN varies by country. In this study, we would like to present the evaluation of benign thyroid nodules in Lithuania in 2018 – 2022.Material and methods: The medical history of 719 patients treated for thyroid nodules (TN) in the Hospital of Lithuanian University of Health Sciences Kaunas Clinics Endocrinology and Surgery departments from 2018...

Introduction: Epidemiological studies show that thyroid nodules (TN) are found on ultrasonography in 19-67% of patients, with a predominance in women, the elderly, and populations living in areas with insufficient iodine intake. Approximately 5-15% of nodules are malignant, of which 95% are well-differentiated thyroid carcinomas.Material and methods: The medical history of 377 patients treated for thyroid carcinomas (TC) in the Hospital of Lithuanian Uni...

Objective: To assess olfactory bulbs sizes and define the most common molecular defects in adolescents with congenital isolated hypogonadotropic hypogonadism.Materials and Methods: Single-centre comparative study. 36 patients were included. The main group consisted of 21 patients with mean age of 15.9 years (17 boys, 4 girls) with congenital isolated hypogonadotropic hypogonadism (IHH): 13 - with Kallmann syndrome (KS), 8 – with normosmic isolated h...

SARS-CoV2 can induce multiple immunological and endocrinological changes. Diabetes and thyroid disorders tend to coexist in patients. Both conditions involve a dysfunction of the endocrine system. Thyroid disorders can have a major impact on glucose control. On one hand, thyroid hormones contribute to the regulation of carbohydrate metabolism and pancreatic function, and on the other hand, diabetes affects thyroid function tests to variable extents. SARS-CoV-2 uses ACE2 recept...

Type 2 diabetes mellitus (T2DM) is an insulin-resistant state characterized by an increased low-level inflammation and oxidative stress which are probably the initiation of diabetes-related cardiovascular complications. The aim of the study was to evaluate the impact of Mediterranean-style diet on inflammation and atherosclerosis markers in T2DM patients. Twenty-five overweight/obese T2DM patients (age 54.1±1.9 years, diabetes duration 7.8±1.3 years, HbA1c...

Introduction: Ukrainian population is facing many challenges of war including chronic stress, D deficit, often unavailability of medical care. In these conditions some diagnostic disadvantages of Diabetes Mellitus type 2 (DM 2) patients’ status are also observed1. According to Ukrainian Consensus on Diagnosis and Management of Vitamin D Deficiency in Adults, approximately 20% of Ukrainian population has Vit D deficit (VDD) and 27% Vit D insufficiency (VDI)...