Endocrine Abstracts

Cosyntropin stimulation test is the gold diagnostic standard used to test for NCAH. Genetic testing is not currently considered to be the primary diagnostic tool for NCAH. Still, it may be helpful in establishing a diagnosis if other results are unequivocal or for genetic counselling purposes. The study aimed at verifying the currently accepted threshold of 17-hydroxyprogesterone (17OHP) level (3 2.0 ng/ml) at which a cosyntropin stimulation test should be performed...

Familial non-medullary thyroid cancer (FNMTC) constitutes about 3–9% of all thyroid cancers. One of the genes believed to predispose to non-syndromic FNMTC is FOXE1. It contains a polyalanine tract (polyAla) with a variable number (11 – 22) of alanine residues. This length polymorphism could lead to changes in the FOXE1-encoded protein (FOXE1 transcription factor) structure and predispose to papillary thyroid cancer (PTC). The aim of the st...

Introduction: There are data reporting an increased risk of cardiovascular and metabolic complications in patients with NCAH. This is frequently attributed to glucocorticoid (over)use. It seems that long-term exposure to increased androgens concentration may also itself lead to diminished insulin sensitivity and increased risk of prediabetes and diabetes.Aim: The aim of the study was to assess the link between NCAH diagnosis and glucose metabolism distur...

Up to 5% of all pituitary tumors are hereditary (e.g. due to menin or AIP genes mutations). AIP gene mutations are more common in subjects with acromegaly, less than 30 years old at the onset of disease, and with FIPA family history. The study was aimed at the assessment of the frequency and characteristics of AIP-mutation related tumors in non-selected patients with pituitary macroadenomas.Material and Methods: The study included subsequent 131 patients...

Background: Double pituitary adenomas are a rare entity, which requires clinical attention and a careful follow-up.Case report: A 37-year-old man presented with left-sided painful gynecomastia. He denied typical symptoms of excessive growth hormone (GH) secretion and did not show any acromegalic features. Due to low testosterone and LH levels with mild hyperprolactinaemia, the patient was referred to pituitary MR, which revealed an 11 × 13 mm right-...

CHEK2, located on chromosome 22q, is a tumor suppressor gene. Its’ pathogenic variants are often associated with a tumor predisposition syndrome 4, with an increased risk of breast, prostate and colorectal cancers. There are some reports of an increased risk of papillary thyroid cancer (PTC) in carriers of the CHEK2 pathogenic variants. Current guidelines, however, do not recommend general screening of TC patients. The study assessed the prevalence of pa...

Introduction: Dendritic cells (DCs) are considered as main regulators of immune system. Functional properties of DCs depend on their subtype, maturation status, interaction with other immune cells as well as environmental factors including hormones. Recently, we have shown a direct, independent of TSH, regulatory influence of thyroid hormones on human DCs function. The aim of the present study was to analyze ex vivo the effect of systemically administered TSH on human...

Introduction: Vitamin D deficiency is observed across all age groups and both sexes. Moreover vitamin D deficiency is common in elderly especially along elderly patients. Elderly people are prone to develop of vitamin D deficiency caused by various factors such as deceased dietary intake, impaired intestinal absorption, reduced sunlight exposure, impaired skin synthesis as well as impaired hydroxylation in the liver and kidneys. Vitamin D deficiency may leads to rickets, osteo...

Introduction: Acne vulgaris is the most common skin disorder, which may be sometimes the only early clinical manifestation of hyperandrogenemia. Main role in its pathogenesis play: genetical predisposition as well as hormonal and environmental disturbances, which may begin in puberty. It has been widely discussed at what age and what kind of diagnostics should be performed in this area.Aim of the study: Was to evaluate concentrations of selected hormones...

Introduction: Despite recommendations neuroendocrine tumors may still pose diagnostic and therapeutic problems. Patients are referred to specialized centers when their disease has already progressed to generalized stage.Case report: A 64-year old male patient was referred to the Department of Endocrinology at the Pomeranian Medical University in 2013 because of liver metastases. His medical history included a surgical treatment of left lung tumor in 2006...