Endocrine Abstracts

Introduction: Pituitary apoplexy (PA) is a rare endocrine emergency with less described entity being its subacute/non-acute presentation. Incidence of PA is difficult to determine, varying 2%-12% of pituitary adenoma. Hypopituitarism in PA is observed in up to 70% of cases with diabetes Insipidus (DI) observed in <5% of cases and mostly transient.Case description: 82-year old female with pituitary macroprolactinoma (1.5 cm) presented with 3-week hist...

A 22-year-old woman with hypophosphataemic rickets was diagnosed at age four when she presented with short stature and valgus deformity of the lower limbs. Biochemical testing, genetic screening and radiological investigation of her family showed no abnormality and it was concluded that she had a de novo mutation.She was treated with 1α-calcidol and phosphate Sandoz with regularly monitored biochemistry. She had poor adherence to her medicati...

Introduction: Thyroid cancer (TC) is a rare disease in childhood, with an incidence of 0.2 to 5 cases per million per year or higher [Neiva F., 2012, Tuli G, 2023]. The incidence of malignancy among thyroid nodules in children is about 16%, which is about three times higher than in adults [Vaisman F., 2011, Yeker R.M., 2022]. Lymph node metastases (40–80%) and distant metastases (25%) are also much more common in the pediatric population [Zirilli G., 2018, Thomas JK., 202...

Background and Aims: Metabolic dysfunction-associated fatty liver disease (MAFLD) is a diagnosis of inclusion relying on a set of metabolic risk factors and the presence of hepatic steatosisis; viscerl obesity, insulin resistance, type 2 diabetes (T2D) may often coexist in MAFLD patients. MAFLD is present in up to 80%f of T2D patients. Pioglidazone, a peroxisome proliferator-activated receptor agonist reduce hepatic/visceral fat (HVF) and improve necroinflammation in liver. Du...

Background: To identify opportunities for Doppler ultrasound in the diagnosis of cerebral microangiopathy in patients with diabetes mellitus type 2 and hypertension.Methods: The study included the diagnosis of 72 patients with type 2 diabetes and hypertension who were hospitalized in the 2 and 3 clinics TMA. The control group consisted of 25 patients aged 61.9 ± 2.6 years, suffering from type 2 diabetes. The study group included 47 patients (19 men ...

Background: The study of fundamental questions related to the analysis of recent advances in the field of cellular and molecular pathways involved in lung organogenesis provides a basis for understanding the pathogenesis of acute and chronic diseases of this organ. Cells of the diffuse endocrine system - apudocytes (APUD) absorb the precursors of biogenic amines introduced from the outside and subject them to decarboxylation with further formation of biogenic amines and peptid...

Objective: To study the life quality of patients with subclinical hypothyroidism by using questionnaire SF-36 before and after replacement therapy.Methods: All patients were collected at the Department of Endocrinology 3rd clinics of Tashkent Medical Academy. The study included 55 women with subclinical hypothyroidism and 20 women for the control group. The age surveyed had an average of 37,6 &pm; 8,83 years. Patients included in the study do not take re...

Introduction: Simultaneous pancreas-kidney transplantation (SPKT) is the best way to restore normoglycemia and renal function in patients with type 1 diabetes mellitus (T1D) and end-stage renal disease (ESRD). Pregnant patients after SPKT are a high-risk group for adverse events/loss fetal and transplantation organs. These risks are significantly reduced due to pregnancy planning, regular monitoring of the woman and fetus condition with timely correction of immunosuppressive t...

Background and Aims: The metabolic-associated fatty liver disease (MAFLD) is a fatty liver accumulation with metabolic dysfunction (diabetes, overweight/obese, insulin-resistance), a definition more practical for identifying patients with fatty liver disease with high risk of disease progression. The triglyceride-glucose (TyG) index is a marker of insulin resistance. Long-term fasting plasma glucose (FPG) variability is associated with fatty liver content (FLC). Continuous glu...

Introduction: Familial hypocalciuric hypercalcemia (FHH) is a benign condition characterized by asymptomatic hypercalcemia secondary to hypocalciuria. Affected patients have variable parathyroid hormone levels. It is caused by a loss-of-function mutation in the calcium-sensing receptor (CASR) gene. The occurrence of both FHH and primary hyperparathyroidism (PHPT) in the same patient has rarely been described. We report an interesting case.Case: ...