Endocrine Abstracts

Introduction: The role of mitotane as an adjuvant therapy for adrenocortical carcinoma (ACC) remains a contentious topic due to the scarcity of robust randomized clinical trials, attributed to the low incidence of this neoplasm. Despite this, the prognosis following surgery for localized tumors is generally poor, leading to varied clinical practices.Methods: This study utilized patient data from the ICARO registry of the GETHY group and SEEN, with diseas...

Introduction: The interaction between corticosteroids and protease inhibitors (PIs) is a clearly described drug interaction.Case report: A 44-year-old woman diagnosed with HIV category B3 diagnosed in 1989; severe lipodystrophy. In addition , HCV genotype IA. Bronchial asthma since 2000. Treatment with fluticasone 1 inh/24 h, salbutamol on demand, darunavir 800 mg/day and ritonavir 100 mg/day. He had known lipodystrophy since 2001 and the abdominal perim...

Multiple sclerosis (MS) is an inflammatory and neurodegenerative disease of the central nervous system. Genetic and environmental risk factors are likely operative in MS pathobiology. MS prevalence varies from very low rates in peri-equatorial regions, to over 100/100 000 population in temperate regions distant from the equator- prompting consideration of limited sunlight and vitamin D insufficiency as potential risk factors for MS. In a large study of MS patients living in te...

Introduction: Malignant struma ovarii is a rare disease, for which risk factors and prognostic features are not well-defined. We present a patient with concomitant Graves’ disease and metastatic follicular thyroid cancer arising from struma ovarii, and discuss the possible mechanism of this association.Clinical case: A 43 year old woman undergoing follow-up for Graves’ disease (GD) presented with an enlarging left lower abdominal mass. She ha...

The dampening of hypothalamic–pituitary–adrenal (HPA) axis responses to a repeated stress is termed HPA habituation. We investigated here the effects of two commonly used repeated restraint stress paradigms, in which rats are exposed either to 10 episodes of 0.5 h restraint or 5 episodes of 3 h restraint. We compared ACTH, corticosterone, and testosterone responses, as well as corticotropin-releasing hormone (CRH) and arginine vasopressin (AVP) mRNA levels within bra...

Although it is becoming increasingly clear that testosterone exerts an inhibitory influence on stress-induced adrenocorticotropin (ACTH) and corticosterone release, where and how this occurs in the brain remains poorly understood. We previously determined that androgen receptors are not distributed within anterior pituitary communicating neurons of the paraventricular nucleus (PVN) of the hypothalamus (Bingham et al. J Comp Neurol 2006). However, they are contained with...

Background: Continuous glucose monitoring (CGM) measures interstitial glucose and display trends arrows, showing the direction and rate of change in glucose. Trend arrows allow the child/youth to take action to prevent hypo- and hyperglycaemia. Effective strategies for adjusting insulin boluses for trend arrows are lacking. The JDRF CGM Study Group recommended a 10/20% increase/decrease in the insulin dose. However this formula requires a mathematical calculation with each tre...

Background and aims: Pituitary apoplexy (PA) is a rare clinical syndrome due to pituitary hemorrhage or infarction. It is an emergent and potential life-threatening complication of pituitary adenomas if not managed properly. It is usually characterized by the sudden onset of one or more of the following: severe headache, visual disturbance, nausea/vomiting, and or altered mental status. We aimed to present clinical and biochemical characteristics as well as management of patie...

Background: Various genetic syndromes have identified distinct and consistent behavior patterns. Carney complex (CNC) is a rare multiple endocrine neoplasia syndrome first described by Dr Carney in 1985 as a complex of myxomas (cardiac, skin), spotty skin pigmentation, and endocrine over activity. CNC is caused by mutations of the PRKARIA gene that encodes the RIα regulatory subunit of Protein kinase A (PKA). We recently reported that a Prkar1a heterozyg...

Background: Gonadal failure is a well-recognized long-term complication of bone marrow transplantation (BMT) in children with acute lymphoblastic leukemia (ALL). Identifying key risk factors is helpful in planning and counselling for hormone replacement therapy (HRT) and in targeting future research.Objectives: To determine the prevalence and risk factors for primary gonadal failure (PGF) in childhood ALL treated with BMT in a single centre.<p class=...