Endocrine Abstracts

Introduction: Opioid system activity was found disturbed in several reward circuit areas in restrictive anorexia nervosa (AN) patients but also surprisingly at the pituitary level. However, the potential role of this specific abnormality of pituitary in AN physiopathology remains unclear or unknown.Objectives: The first aim was to find the exact pituitary location (posterior and/or anterior) of this disturbed opioid activity and then to study the link be...

This talk will cover the currently available evidence describing the endocrine and metabolic consequences of radiotherapy treatment to the hypothalamus and pituitary. A practical approach to surveillance, diagnosis and management of these consequences in childhood and adult cancer survivors will be provided....

Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, importan...

Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...

Glucocorticoids are effective for the treatment of many chronic conditions but their use is associated with frequent and wide-ranging adverse effects including osteoporosis and growth retardation. The mechanisms that underlie the undesirable effects of GCs on skeletal development are unclear and there is no proven effective treatment to combat them. An in-vivo model that investigates the development and progression of GC-induced changes in bone is, therefore, importan...

Cancer and treatments for cancer can have a significant impact on bone health in both children and adults. There are emerging data that bone mineral density is often reduced in survivors of childhood cancers and survivors of both solid tumours and haematological malignancies in adults. Fracture rates in childhood cancer survivors have not been shown to be increased. Older adult cancer survivors, particularly those treated with aromatase inhibitors and androgen deprivation ther...

Background: Hypothyroidism is characterised by insufficient secretion of the thyroid and its detection measured by elevated serum TSH levels.Although relatively common during pregnancy, untreated maternal hypothyroidism is associated with adverse obstetric and neonatal outcomes such as preeclampsia, placental abruption and miscarriage, or foetal neurodevelopment defects.Highlighting a nurse led specialised telephone clinic in the c...

Case History: A 26 year old female patient was referred to her local endocrine clinic having presented to her GP complaining of ankle swelling. Routine biochemistry revealed a suppressed TSH (<0.05 U/l), and reduced serum levels of free T4 (2.0 pmol/l) and T3 (3.2 pmol/l). Random serum cortisol measurements were also elevated on 2 separate occasions (1266 nmol/l and 991 nmol/l). Clinical examination revealed her to be clinically euthyroid with no evidence of ...

Case History: A 26 year old female patient was referred to her local endocrine clinic having presented to her GP complaining of ankle swelling. Routine biochemistry revealed a suppressed TSH (<0.05 U/l), and reduced serum levels of free T4 (2.0 pmol/l) and T3 (3.2 pmol/l). Random serum cortisol measurements were also elevated on 2 separate occasions (1266 nmol/l and 991 nmol/l). Clinical examination revealed her to be clinically euthyroid with no evidence of ...

Introduction: GH neurosecretory dysfunction (NSD) refers to children with abnormal auxology, normal GH responses to provocative testing, but with impaired spontaneous GH secretion over 24 h, leading to low IGF1 concentrations. It is thought to be due to abnormal hypothalamic function with aberrant GHRH and somatostatin secretion leading to impaired GH secretion and subsequently suboptimal growth.Methods: We reviewed children admitted for spontaneous GH s...