Endocrine Abstracts

Introduction: Liraglutide is a glucagon-like peptide 1 (GLP-1) receptor agonist, approved for the treatment of adult patients with type 2 diabetes mellitus of a particular interest in the significant improvement of glycaemic, systolic blood pressure and lipid control with their impact on weight, making it possible to avoid this infernal spiral of weight gain-increased insulin resistance.Observation: 55-year-old female patient, known diabetic for 10 years...

Introduction: Most pituitary adenomas are benign. However, there are invasive forms with rapid growth rate and particular histological signs (atypical adenomas), making them considered pituitary carcinomas without metastases.Observation: A 63-year-old patient was followed for 10 years for Cushing’s disease in the pituitary macrodenoma. Clinical evaluation found Cushing syndrome, pituitary tumor syndrome associated with diplopia, and trigeminal neura...

Introduction: LADA (Latent Autoimmune Diabetes in Adults), is defined by the association of diabetes after 30 years, the presence of antibodies against pancreatic beta cells and the non-use of insulin therapy within 6 months of diagnosis. Graves’ disease is the first cause of hyperthyroidism associating thyrotoxicosis, goiterand exophthalmos with a prevalence 5 times higher in women.Case report: 37-year-old female patient with no notable history, la...

Introduction: Primary hyperparathyroidism is a frequent pathology, its association with papillary thyroid carcinoma is rare.Case Report: A 53 year old patient was admitted for management of primary hyperparathyroidism. The biological work-up showed a blood calcium level of 120 mg/l, parathyroid hormone (PTH) 4 times the normal range and hypophosphatemia. Cervical ultrasound showed a right parathyroid nodule with thyroid nodules classified Tirads 4, MIBI ...

Introduction: Cushing’s disease is characterized by an endogenous hypercortisolism related to a pituitary adenoma, its association with an empty sella turcica is exceptionally rare.Case report: A 55 year old diabetic patient with hypertension was admitted for investigation of Cushing’s syndrome. Clinical examination found facial and truncal obesity with facial erythrosis, capillary fragility with multiple ecchymoses, proximal amyotrophy of the ...

Introduction: The association of papillary carcinoma with medullary thyroid carcinoma may in rare cases be found in some members of families with multiple endocrine neoplasia type 2a (MEN 2a).Case Report: A 38-year-old patient with a family history of papillary thyroid carcinoma (PTC), operated for multinodular goiter classified Tirads 4 by total thyroidectomy, the anatomopathological examination concluded to a lobar medullary thyroid carcinoma (MTC) of ...

Introduction: Androgen insensitivity syndrome (AIS) is a genetic sexual developmental disorder (DSD) inherited in an X-linked recessive mode, responsible for 30 to 70% of cases of DSD 46, XY. Androgen insensitivity can be complete (CAIS), partial (PAIS) or mild depending on the degree of receptor sensitivity to androgen stimulationCase report: A 17-year-old female patient with a history of inguinal hernia operated in childhood who was admitted for explor...

IntroductionCirculating cell-free deoxyribonucleic acid (cfDNA) is a topical subject that has proven its place in oncology. However, its regular use is always compromised by the relatively high cost of the technique. The objective of our study is to determine the usefulness of cfDNA in the management of obese patients with breast cancer as well as its prognostic impact.MethodsUsing real-time multiplex polymer...

IntroductionAltered levels of circulating cell-free deoxyribonucleic acid (ccf DNA) have been found in several pathologies and might have a diagnostic value. With the steadily growing number of studies in the issues related to obesity research, it is proven, that obesity might be related to wide number of body disorders. In the current opinion, we hypothesized that there is a correlation between obesity and elevated cfDNA levels in the circulation.<p...

Background: Pheochromocytoma is a rare tumour that arise from chromaffin cells in the adrenal medulla and produces signs and symptoms due to excessive catecholamine secretion from tumour. Presenting symptoms can vary but often they classically present with headaches, sweating and palpitations in the setting of paroxysmal hypertension. Pheochromocytoma crisis results from the sudden release of large quantities of catecholamines and leads to progressive multiple organ dysfunctio...