Endocrine Abstracts

As information scales in non clinical environments, people are faced with challenges as to what information is relevant to healthcare teams. PeopleWith is a digital health company developing solutions to help people engage with their health. Patients who engage with their health get better treatment outcomes. How do we support patients on this journey to become fully activated in their health and become a participant in conversations to optimise outcomes....

Information is becoming increasingly available in non clinical environments with the scale in functionality in smart mobile devices, wearables and home health devices. This creates a challenge for patients and Clinicians as to what information to capture and how to present and share it. PeopleWith has been developed by a healthcare veteran with 30 years experience working in Nursing and the Pharmaceutical industry. This information is known as Patient generated health data and...

Information is becoming increasingly available in non clinical environments with the scale in functionality in smart mobile devices, wearables and home health devices. This creates a challenge for patients and Clinicians as to what information to capture and how to present and share it. PeopleWith has been developed by a healthcare veteran with 30 years experience working in Nursing and the Pharmaceutical industry. This information is known as Patient generated health data and...

Post-translational modifications of histones such as methylation, acetylation, and phoshorylation regulate chromatin structure and gene expression. However, phosphorylation of histone H3 at threonine 11 (H3T11ph) has not been linked to transcriptional regulation. Here we show that protein kinase C-related kinase 1 (PRK1) phosphorylates H3T11 upon ligand-dependent recruitment to androgen receptor (AR) target genes. PRK1 is pivotal to AR function since PRK1 knockdown by RNAi or ...

Introduction: Chronic hypercortisolemia during Cushing Syndrome (CS) determines significant changes in the plasticity and function of metabolic tissues like visceral adipose tissue (VAT). Persistence of alterations in VAT function after CS remission is under debate, as data of clinical studies is not consistent due to confounder factors and limited availability of VAT. Animal model of reversible CS presents long-term alterations on VAT after remission. We investigate VAT alter...

Mark E Molitch, Feinberg School of Medicine, Northwestern University, Chicago, IL, USA AbstractMark E. Molitch, MD, is Professor of Medicine and a Member of the Division of Endocrinology, Metabolism and Molecular Medicine at Northwestern University Feinberg School of Medicine, in Chicago, Illinois. Prior to joining the faculty at Northwestern in 1984, Dr. Molitch was an Associate Professor at Tufts University School of...

The pituitary gland, is a small midline organ situated at the base of the brain, that acts as a master regulator of multiple physiological functions: such as growth, puberty, metabolism, stress response, reproduction and lactation. The pituitary gland is composed of three lobes: the anterior and intermediate, which form the anterior pituitary (AP and contains hormone producing cells), and the posterior lobe which constitutes the posterior pituitary (PP contains axonal inputs)....

A 62-year-old lady was assessed following discovery of a retroperitoneal tumour on a CT scan. Fifteen years previously she was diagnosed with irritable bowel syndrome with alternating constipation and diarrhoea, however, within the last 5 years, diarrhoea was the dominant feature with bowel opening every 20 min daily. Investigations for inflammatory bowel disease, hyperthyroidism and coeliac disease were negative. Her anal sphincter was found to be non-functioning and a colost...

The adrenal cortex is a dynamic organ that undergoes self-renewal. In the mouse it is divided into two concentric layers, the outer zona glomerulosa (ZG) and the inner zona fasciculata (ZF), that secrete aldosterone and corticosterone, respectively. Capsular and subcapsular stem/progenitor cells differentiate and migrate in a centripetal fashion to repopulate the gland until they reach the juxtamedullary region where they undergo senescence and apoptosis. Cell fate mapping stu...

Patterns of food consumption have a profound influence on hormone rhythmicity and fat storage, but until now only crude manipulations of food availability have been possible in rodents. We have used a CLAMS-based system in conjunction with automated serial blood sampling to investigate the effect of continuous feeding on ghrelin secretion and adiposity. Six-week old male Sprague–Dawley rats (n=6) were housed in metabolic cages and ad-libitum fed with standar...