Endocrine Abstracts

In several studies, the state of the endothelial function is analyzed in clinical thyrotoxicosis. Increased level of von Willebrand factor is detected. Many events of association of trombosis at these patients with high level of VWF are described. An association between autoimmune thyroid disease and pulmonary arterial hypertension (PAH) has been reported too. We have studied factors which influence on level of VWF at patients with a clinical thyrotoxicosis of a various genesi...

Objective: The aim of our study was to evaluate the possibility of maintaining the metabolic effects of liraglutide 3.0 mg treatment after it’s cessation.Methods: The study included 8 patients with type 2 diabetes (T2D) and obesity who received liraglutide 3.0 mg daily for 9 months. All of them successfully reduced body weight, insulin resistance level (IR), volume of visceral adipose tissue, HbA1c level. After discontinuation of liraglutide in 2019...

Actuality: Diabetes is one of the largest global health emergencies of the 21st century. Each year more and more people live with this condition, which can result in life-changing complications. In addition to the 415 million adults who are estimated to currently have diabetes, there are 318 million adults with impaired glucose tolerance, which puts them at high risk of developing the disease in the future (International Diabetes Federation, 2015). The prevalence of patients w...

Introduction: Obesity worsens the prognosis of diabetic patients by increasing the cardiovascular risk and chronic complications. Waist circumference, as a brief indicator of visceral obesity, is associated with multi-metabolic disorders and cardiovascular diseases. The aim of the study was to report the prevalence of WC in individuals with diabetes and find out their association with other cardiovascular risk factors.Material and Methods: We performed a...

Somatotropin (GH) and IGF1 realise their influence on the system of intracellular metabolism and a number of important biochemical lymphocytes reactions through the receptor apparatus. It is allows to use the peripheral blood lymphocytes as the investigations object of intracellular metabolism disorders in acromegaly.Aim: To study the NAD- and NADP-dependent dehydrogenases activity in blood lymphocytes in active acromegaly patients.<p class="abstext"...

Introduction: The association between diabetes and adverse cardiovascular outcome may be partially explained by the strong independent association of type 2 diabetes with cardiovascular target organ damage, such as left ventricular hypertrophy (LVH), a well-known predictor of cardiovascular events independent of coronary artery disease. The aim of the present study is to evaluate the relation of LVH to fibrinogen and C-reactive protein (CRP) as markers of inflammation and susc...

Syndrome of inappropriate antidiuresis hormone (SIADH) with many disorders of the nervous system have been reported frequently but its association with multiple sclerosis (MS) is extremely rare (only six cases reported in the literature).A 46 years old woman was admitted to our hospital because of hypersomnolence, confusion and visual disturbances. She presented 6 months before a variety of neurological symptoms suggestive of demyelinating disease withou...

Background: Microalbuminuria was originally established as a predictor of renal failure and an independent risk factor for cardiovascular disease in patients with diabetes mellitus as well as in general population. The aim of our study is to assess the relationship between microalbuminuria and the other risk factors in diabetics and their prevalence.Methods: Sixty five patients, 22 men and 43 women with mean age 58.6±10.09, with type 2 diabetes, wer...

The routine approach to evaluating the effectiveness of diabetes treatment based on the level of glycated hemoglobin (HbA1c) accounts for the average glucose level but does not consider its fluctuations. However, recent data indicate that the development of late complications of diabetes is associated with the degree of variability in glycemia. (GV).Clinical case: Patient F. is 54-year-old woman with a 33-year history of type 1 diabetes with multiple chr...

Introduction: Graves’ disease (GD) is organ-specific autoimmune-inflammatory disorder characterized by a complex pathogenesis. The inflammatory process is dominated by an imbalance of the antioxidant-oxidant mechanism, increased production of reactive oxygen species (ROS), which can potentiate the cytotoxicity of neutrophils and sustain the autoimmune process and perpetuate the disease. Aim: to study the level of ROS synthesis by peripheral blood neutrophils in patients w...