Endocrine Abstracts

Introduction: The fine needle aspiration cytology (FNAC) of thyroid nodules is the procedure of choice in the diagnostic approach of nodular thyroid disease. Despite showing a sensitivity of 83% and a specificity of 92%, many of the results are non-diagnostic. One of the factors that can contribute to this number is the proper procedure of the smear.Objective: To compare the FNAC’s results in our team with and without the contribution of an expert C...

Background: Survival rate after childhood cancer has improved markedly and today more than 80% of patients with a pediatric malignancy will become 5-year survivor. During the past years it has become evident that many childhood cancer survivors suffer from late complications due to the radiotherapy and chemotherapy. It is established that the largest childhood cancer group, the acute lymphoblastic leukemia (ALL) survivors, exposed to cranial radiotherapy are at particularly hi...

: We analyzed the occurrence of adrenocortical tumors in transgenic mice expressing Simian Virus 40 T antigen (SV40Tag) under the inhibin-α promoter (inhα/Tag) and searched for novel biomarker genes for the tumorigenesis. We studied 2-, 4-, 6-mo-old intact (never forming tumors) and prepubertally gonadectomized (GDX) inhα/Tag mice (developing tumors) and similar groups of wild-type mice as controls. Furthermore, the role of ectopic luteinizing hormone receptor (...

Background and aims: Type 2 Diabetes Mellitus affects a growing number of people allover the world. It is associated with serious complications. Several studies have shown that it is possible to prevent and minimize type 2 diabetes complications if it is treated appropriately over time. In our Hospital there is, since 1998, an outpatient clinics of diabetes. This study aimed to determine the quality of care provided to diabetic patients in our institution.<p class="abstext...

Context: The aldosterone to active renin ratio (AARR) is the recommended screening test for primary aldosteronism (PA), but prospective study data on its sensitivity and specificity are sparse.Objective: We investigated the diagnostic accuracy of the AARR for detecting PA.Design: This is a prospective diagnostic accuracy study.Setting: This study was conducted from February 2009 to August 2015 at the outpatie...

Arterial hypertension is a major health problem affecting 1.13 billion people worldwide, of which 10% could be due to endocrine pathologies related to the mineralocorticoid receptor (MR) (i.e. primary aldosteronism, 11β-hydroxysteroid dehydrogenase type 2 enzyme (HSD11B2) deficiency). The MR pathway is expressed mainly in placenta, kidney and colon epithelial cells. Current research highlights potential epigenetic regulatory mechanisms for the MR pathway. Here, specific m...

Introduction: The prevalence of hypertension in children and adolescent who were extremely preterm newborns (EP; ≤32 gestational weeks) has been found to be higher than in those born at term. The causes have not been well characterized. Studies support that adrenal dysregulation might be a consequence of prematurity.Objectives: To determinate if children who were EP had higher adrenal hormones and vascular remodeling biomarker than term newborn (&#...

Introduction: Soluble ST2 (sST2) is the truncated soluble form of the ST2 receptor in the circulation. It is a decoy receptor of IL-33 and thereby inhibits the effects of IL-33/ST2 signaling. Elevated levels of sST2 have been associated with various adverse cardiovascular outcomes. Recently, potential associations of sST2 with obesity and type 2 diabetes mellitus (T2DM) have been described in the general population. In this study, we determined possible cross-sectional associa...

Introduction: Unbalanced diabetes mellitus predisposes to bacterial and fungal infections especially candidiasis. Candidiasis can have several localizations including digestive, genitourinary or mucocutaneous. The purpose of this work was to analyze the characteristics of candidiasis in all these forms in the patient.Materials and Methods: Descriptive cross-sectional study from January 2012 to December 2018, including 307 diabetic patients presenting wit...

Patients with growth hormone deficiency (GHD) have many clinical features in common with Cushing’s syndrome (glucocorticoid excess) - notably visceral obesity, insulin resistance, osteoporosis and increased vascular mortality. Within key metabolic tissues, 11β-hydroxysteroid dehydrogenase type 1 (11β-HSD1) converts cortisone to the active glucocorticoid, cortisol, and thus amplifies local glucocorticoid action. We hypothesise that 11β-HSD1 expression is neg...