Endocrine Abstracts

Background: Primary bilateral bilateral macronodular adrenal hyperplasia is a cause of Cushing’s syndrome. It is characterised by a large enlargement of the adrenal glands at the expense of multiple non-pigmented nodules. There is inefficient steroidogenesis.Summary of the case: A 58-year-old woman with a history of extreme obesity, type 2 diabetes mellitus, hypertension and dyslipidaemia was admitted to our hospital for cellulitis and anaemia secon...

Introduction: Ketosis-prone diabetes or Flatbush diabetes has been recognized as a clinical entity since 1984. Is characterized by diabetic ketosis or ketoacidosis occurring soon after the onset of hyperglycemic syntoms (usually poyiuria, polydipsia and weight loss are present for less than 4 weeks). Unlike the insulin dependence seen in type 1 diabetes, after a few weeks (usually 2 to 12 weeks), insulin requeriments decrease, and approximately 70% of patients achieve remissio...

Cardiovascular disease (CVD) is more prevalent in patients with chronic kidney disease (CKD) and Diabetes mellitus (DM) than in the general population. Microparticles (MPs) released during cell activation and/or apoptosis could be biomarkers of CVD. These MPs, which show vascular damage, are named according to the injured cell, as endothelial (EMPs) or platelet (PMPs).AimAssess the MPs plasma concentration in diabetic pati...

Introduction: NutriScore is a tool designed with the aim of simplifying the information of the nutritional composition obtained from the labelling. It classifies foods into five colors ranging from green (healthier) to red (less healthy). These colors are associated with five letters (A/B/C/D/E).Objective: To examine the nutritional value of foods sold in vending machines of the public hospitals in Community of Madrid (Spain), by calculating the nutrisco...

Introduction: Pancreatic neoplasms portray the 12th most prevalent neoplasm worldwide, determining a five-year survival of only 5 to 10% including all stages. Despite tumoral aggressiveness, the modified Appleby procedure can be performed in selected patients, representing a curable alternative in borderline-resectable or locally advanced pancreatic tumors’ treatment in the context of a multimodal practice. Objectives: This work aims to review the state of the art regardi...

Oxytocin was discovered by Henry Dale in 1906 and synthesized in the early 50’s by Vincent du Vigneaud and coworkers. It is secreted by axonal terminals in the neurohypophysis emanating from the neurosecretory neurons of the supraoptic and paraventricular nuclei of the hypothalamus. This hormone similarly to others is secreted in a pulsatile way and, classically, in relation to labor (uterine contractility), lactation and to the maternal behaviour. After the initial ident...

Introduction: Allograft inflammatory factor 1 (AIF-1) is a putative obesity gene which may influence the function of white adipose tissue (WAT).Objective: To study the role of AIF-1 in human WAT.Design and main outcome measures: mRNA expression and WAT secretion of AIF-1 was determined in subcutaneous and visceral WAT from non-obese subjects. Differentiated human adipocytes were treated with recombinant AIF-1 in vitro.<p...

A 69-year-old lady presented to the ophthalmologists in view of a right 6th cranial nerve palsy and headache. Neuroimaging showed a central and right sided base of skull tumour with involvement of multiple cranial nerves (3rd, 4th, 6th). An endoscopic biopsy was inconclusive. She presented to the medical team few days later with drowsiness, lethargy, and her sodium was found to be 117 mmol/l with a potassium of 5.5 mmol/l. Serum osmolality was 267 mOsm/kg, urine osmolality was...

Allan-Herndon-Dudley syndrome (AHDS) is a genetic disorder characterized by intellectual disability and movement disorders. AHDS patients have mutations in the monocarboxylate transporter 8 (MCT8) that impedes thyroid hormone (TH) transport to the brain during crucial phases of brain development. In mice, the resulting structural and functional pathologies of human AHDS patients can be mimicked by knocking out murine MCT8 and the Solute Carrier Organic Anion Transporter Family...

Introduction: Trans-axillary surgery is an emerging technique for cervical approach with fantastic cosmetic result. With more than 50 cases treated by our group, we developed our technique with specific safe methodologies.Aims: To present step-by-step technique of trans-axillary endoscopic thyroidectomy.Material and methods: This is a video surgery that uses three trocars and a harmonic scalpel for dissection and ligation. Incision...