Endocrine Abstracts

Background: We evaluated the impact of the multifocality on post-lobectomy recurrence in patients with differentiated thyroid cancer (DTC).Methods: We analyzed 1,684 patients with DTC who underwent thyroid lobectomy from 2008 to 2015 using logistic regression models to calculate the relative risk on post-lobectomy recurrence.Results: Tumor diameter increased from 4.9 mm to 8.1 mm and the proportion of extrathyroidal extension (ETE)...

Introduction: Antithyroidal drug (ATD) therapy is considered as choice of treatment for Graves’ disease; however, the response of treatment varied between patients. Although several studies reported risk factors for relapse after initial treatment, there were few studies for the responsiveness during early treatment period.Method and design: We reviewed 94 patients with Graves’ disease and used their initial TSH receptor antibody (TSHRAb) titre...

Background: The acitivity of the TSH receptor stimulating antibody is known to be associated with Graves’ eye disease. However, the association between antibody titer and thyroid function was not significant, in previous studies. Taking into account the continuous changes in antibody titer and thyroid function during treatment, the association between thyroid function and clinical factors needed to be analyzed using panel analysis.Methods: A total o...

Introduction: Anti-thyroidal drug (ATD) therapy is a treatment of choice for Graves’ disease because of its effectiveness and low rate of adverse effect. Response to ATD or remission rate varies among individuals, although there were few useful clues for prediction of treatment response. We applied neural network model to predict response to methimazole, based on clinical symptoms at initial clinical symptoms.Methods & Design: We reviewed 20 new...

Background: There are a lot of painless thyroiditis cases without symptoms diagnosed on health check up or thyroid hormone screening, but there is a few data about it compared to much data about painful subacute thyroiditis. So, we collected data about diagnostic routes, laboratory and clinical characteristics of painless thyroiditis.Method: Painless thyroiditis patients diagnosed between 2010 and 2016 were reviewed. We defined painless thyroiditis as di...

Cytochrome P450 (CYP) 1A1 plays a major role in the metabolic activation of procarcinogens to carcinogens via aryl hydrocarbon receptor (AhR) pathway. In estrogen responsive cancers, 17β-estradiol (E2) may influence on AhR dependent expression of CYP1 family via the interaction between estrogen receptor (ER) and AhR. In the present study, the effect of E2/ER on the expression of AhR and CYP1A1 genes was investigated for BG-1 ovarian cancer expressing ER. In reverse transc...

Genetically engineered stem cells may be advantageous for gene therapy against various human cancers due to their inherent tumor-tropic properties. In this study, we employed human neural stem cells (HB1.F3; hNSCs) transduced with genes expressing Escherichia coli cytosine deaminase (HB1.F3.CD) and human interferon-beta (HB1.F3.CD.IFN-β) as a treatment strategy for human lymph node metastatic colorectal cancer. CD can convert the prodrug 5-fluorocytosine (5-FC) to its act...

Cigarette smoke (CS) is well known to be very harmful to human body functions such as fertility, reproduction, and development. To elucidate the effect of CS on women’s fertility more definitely, we examined the histophaological characteristics of the uterus and ovary samples received from Korean Conformity Laboratories (KCL), which were obtained from the female rats exposed to the different amounts (low, medium, and high concentrations) of smoke of the standard cigarette...

Triclosan (TCS) is an endocrine-disrupting chemical and has a potential to increase progression of hormone responsive cancers as does 17β-estradiol (E2). 3,3′-diindolylmethane (DIM), a phytoestrogen, has been known to have anticancer activity. In this study, we examined the anti-proliferative and anti-epithelial-mesenchymal transition (EMT) effects of DIM on TCS or E2-induced EMT of MCF-7 breast cancer cells, which express estrogen receptors (E...

As a phytoestrogen, kaempferol plays a chemopreventive role inhibiting cancer formation and progression. In this study, chemopreventive activity of kaempferol was examined by measuring its effect on growth, epithelial-mesenchymal transition (EMT), and migration of MCF-7 breast cancer cells increased by 17β-estradiol (E2, a positive control) or triclosan (TCS), an endocrine-disrupting chemical (EDC). As an EDC, TCS is known to interfere estrogen receptor (ER) dependent pat...