Endocrine Abstracts

Introduction: Excessive iodine intake can cause iodine overnutrition, goiter and other thyroid disease. This study is to probe the determinants of children’s iodine nutrition and their goitrous and nodular prevalence in areas with excessive iodine in drinking water in Hebei province of China. Methods Three townships were selected by simple random sampling among the 8 townships with median water iodine being 200–300 μg/l in Hengshui prefecture of Hebei province. ...

Background: Thyroid damage is known to occur during experimental iodine-induced goiter. MicroRNAs (miRNAs) are a class of small non-coding RNAs regulating gene expression. Dysregulation of specific miRNAs can interfere with tissue homeostasis. The purpose of this study was to investigate the dynamic expression profiles of miRNAs during adequate or mild-excess iodine supplementation in the iodine-deficient thyroid.Methods: Hyperplastic goiter was induced ...

IntroductionVarious direct and indirect mechanisms by which glucocorticoid (GC) excess and elevated adrenocorticotropic hormone (ACTH) levels impairs bone metabolism have been described. In the literature, there are different factors described which affect the early outcome of pituitary surgery in patients with CD including preoperative ACTH levels and the clinical severity of the disease. Combining these data, we conducted a retrospective study to inves...

We present a case of a 56 year-old man diagnosed with systemic mastocytosis by the dermatologists on presentation with classical skin lesions, confirmatory bone marrow biopsy and a tryptase level 105 ug/L (NR 2-14). Further genetic testing confirmed KIT D816V mutation. DEXA bone densitometry at diagnosis revealed marked osteoporosis (Lumbar T score -3.7 (Z -3.5), Femoral Neck T score of -2.0 (Z -1.1). He had no history of low trauma fracture and no relev...

We present a case of a 56 year-old man diagnosed with systemic mastocytosis by the dermatologists on presentation with classical skin lesions, confirmatory bone marrow biopsy and a tryptase level 105 ug/L (NR 2-14). Further genetic testing confirmed KIT D816V mutation. DEXA bone densitometry at diagnosis revealed marked osteoporosis (Lumbar T score -3.7 (Z -3.5), Femoral Neck T score of -2.0 (Z -1.1). He had no history of low trauma fracture and no relev...

Introduction: Dual oxidase 2(DUOX2) is NADPH oxidase complex at the apical membrane of the thyroid follicular cells which produce H2O2 required for thyroid hormone synthesis. DUOX2 gene mutation is a well known cause of congenital hypothyroidism (CH), the phenotype depends on the type of mutation and environmental factors.Case: We present a case of 29 years old female delivered a male baby with large neonatal goitre and severe CH who was started immediat...

Stress related cardiomyopathy or Takotsubo LV dysfunction has been described in phaeochromocytoma related cardiomyopathy.16 y female, admitted in A&E on 23 June 2013 with severe epigastric pain, vomiting and dyspnoea. History of episodes of palpitations and exertional syncopal attacks for 2 years, for which she had been investigated. Her symptoms were attributed to panic attacks. There was no known family history of Endocrinopathy. On admission, BP w...

Case History: A 76 year old woman presented to the Accident & Emergency Department with persistent hypokalaemia, hypertension and metabolic alkalosis. She complained of ongoing muscle fatigue and tiredness and denied any headaches or vision problems. On examination, she had evidence of centripetal obesity, proximal myopathy, pink striae and bruises on her abdomen. No visual field deficit on confrontation and neurological examination was normal. She had a past medical histo...

Premature ovarian failure (POF) is defined as cessation of menstruation before the expected age of menopause. The disorder is considerable heterogeneous with a wide spectrum of causes- genetic, autoimmune, metabolic, infectious, and iatrogenic. However, etiology remains to be elucidated in most cases.Chromosomal abnormalities have long been recognized as frequent causes of POF. However, few large cohorts have been studied. Ethnic background is usually no...

The pituitary gland is altered by both anatomical and physiological changes during pregnancy. The most striking finding is the physiological enlargement of the pituitary gland as a result of lactotroph hyperplasia. Hormonal evaluation of pregnant women requires special consideration due to the emergence of the placenta as a new source of hormone production, changes in binding globulin levels and resistance to hormones such as glucocorticoids.Pituitary ad...