Endocrine Abstracts

Introduction: The indications for anti-PD1 agents have expanded considerably in recent years, particularly for the treatment of melanoma, lung cancer and kidney cancer.Hypophysitis is a rare complication of anti-PD1 agents (< 1%) often with an atypical presentation, characterized by a later onset and a less symptomatic presentation.Case report: A 60-year-old woman was diagnosed with a clear cell renal carcinoma, treated with le...

Introduction: Alemtuzumab, a humanized monoclonal antibody against CD52, is effective in the treatment of early relapsing-remitting multiple sclerosis (MS). Thyroid side-effects such as Graves’ disease have been already described. We describe one case of unusual subacute thyroiditis after alemtuzumab treatment.Clinical case: A 38 year-old-female was treated by alemtuzumab for 2 years. She was referred for hyperthyroidism with 10 kg weight loss, diar...

Primary hyperparathyroidism is the third most common endocrine disorder, caused, in the majority of cases, by a single parathyroid adenoma and rarely by multigland adenoma or parathyroid carcinoma. Giant parathyroid adenomas, defined as larger than 3 g, represent an uncommon cause of primary hyperparathyroidism, with only a few cases described in the literature. We present the case of a 47 years old female who presented with a significant, unpainful, left cervical mass associa...

Pheochromocytoma is a rare tumor of the adrenal medulla, responsible for excessive secretion of catecholamines. Symptoms include the classic triad: headache, palpitations and sweating, usually accompanied by hypertension. We report the case of a pheochromocytoma diagnosed following an episode of testicular necrosis. A 72-year-old patient with history of psoriasis and prostate resection underwent emergency surgery for increased testicular pain suspicious of testicular tumor. Pa...

Oncocytic adrenocortical neoplasms (OAN) were first described by Kakimoto et al. in 1986. Since then, only 160 cases have been reported in the literature. There are 3 categories of OANs: pure oncocytic, mixed oncocytic and ordinary adrenocortical with focal oncocytic changes. Although the majority of OANs are considered benign tumors, certain OANs may present similar characteristics to adrenocortical carcinoma, correct histological caractherisation is therefore crucia...

The study of the genetics of diabetes, in its different forms, has produced a huge amount of data only very recently and new information is becoming available as this text is being written. The question, at this time, is: are they any good to our patients?As the study of the genetics of a disease progresses, one would expect several clinical applications, the most obvious being improved prediction and diagnosis, as well as tailored treatment of the disea...

Previous observational studies suggest that low 25(OH)D concentrations in childhoodmight have deleterious effects on vasculature. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed to determine the effect ofone-year vitamin D supplementationon carotid intima media thickness (cIMT) in overweight and obese school children. The current study was a single-blind RCT. A total of 378 children and adolescents, 6&#82...

Glucocorticoids act directly on pancreatic islets suppressing insulin secretion from the beta cells through a genomic mechanism of slow onset. We present here data on immediate actions of dexamethasone on two models of insulin secretion: RINm5F and INS-1 beta cell lines. Under normal glucose concentrations, dexamethasone rapidly (within minutes) decreased insulin secretion about 30%. Under hypoglycaemic conditions (glucose reduced to 50% for 1 hour) dexamethasone increased ins...

Background: Patients with adrenal insufficiency suffer from increased morbidity and mortality. Quantitative evidence on the health-care burden of either primary (PAI) or secondary adrenal insufficiency (SAI) among hospitalized medical patients is scarce.Methods: In this observational cohort study, we analysed nationwide acute care hospitalizations from patients with PAI or SAI, respectively, between 2011 and 2015 using prospective administrative data. Pa...

Introduction: Trials on children and adolescents with excess weight are limited and lack parathyroid hormone (PTH) measures as a surrogate marker of vitaminD status in skeletal health. The present study addresses this key knowledge gap with the use of a dose-response randomized clinical trial (RCT) aimed at determining vitamin D requirement to increase 25(OH)D and suppress PTH concentrations in overweight and obese school children.Methods: The current st...