Endocrine Abstracts

Background: Trans-catheter arterial chemoembolization (TACE) is a method of treatment of unresectable liver metastases from neuroendocrine tumours (NETs) which is effective in the control of symptoms and tumour growth.Aim: To evaluate clinical outcome: radiologic, biologic, symptomatic response and safety of TACE procedure.Method: 31 patients underwent 140 TACE procedures during 2003–2011. Tumour responses were measured by CT ...

Introduction: Most patients with neuroendocrine tumors (NETs) present with liver involvement at the time of diagnosis. Trans-catheter arterial chemoembolization (TACE) is accepted treatment of patients with non-resectable hepatic metastases from NETs.Aim: To analyze objective tumor response and clinical outcome in patients with hepatic metastases from NETs who underwent TACE.Methods: Thirty-one patients underwent 140 TACE procedure...

Background: Antidiuretic analogue desmopressin was tested in its intranasal form in renal colic, with variable effects.Aims: We evaluated the effects of sublingual desmopressin in lithiasic renal colic, alone or combined with a non-steroidal antiinflammatory drug (NSAID).Materials and methods: Our prospective single-blind study included an initial number of 371 patients with lithiasic renal colic randomized as follows: group NSAID ...

Introduction: CT renal tract is commonly requested by the urologists for suspected renal colic as it is recognized as the most accurate technique for the detection of ureteric stones. However, follow-up of adrenal incidentalomas identified on such scans could pose a challenge for the non-endocrinologist. We investigated the prevalence and follow-up of incidentally discovered adrenal masses after CT renal colic.Methods: We looked through the reports of al...

There is scant literature on various mental health parameters following treatment of hyperthyroidism. We present our initial results from an ongoing quality improvement project, jointly undertaken by the Endocrinology and Psychiatry teams.Aim: To evaluate anxiety, depression, ability to work and quality of life (QOL) of patients with hyperthyroidism on presentation and after institution of specific therapy.Method: We assessed 68 ne...

The prevalence of gallstones (GS) is increased in acromegaly and is further increased by somatostatin analogue (SA) therapy. The incidence has variously been reported to be between 10 and 63%, but they are often asymptomatic and rarely require definitive management. However, there is evidence suggesting that discontinuation of SA therapy may precipitate acute biliary problems.We have analysed our experience of symptomatic gallstones in all 44 patients (2...

Objectives: Some authors have defined subtypes within gestational diabetes (GD) based on the calculation, from glucose and insulin levels during oral glucose overload (OGTT), of indices of insulin sensitivity (Matsuda) and insulin secretion (Stumvoll). Powe et al [1] found that 30% of women with GD had predominantly low insulin secretion, 51% low insulin sensitivity and 18% both (mixed). The aim of this work is to analyze the correlation of these indices with other kn...

Introduction: Multiple endocrine neoplasia type 2 is an inherited syndrome characterized by the characteristic combination of medullary thyroid cancer, pheochromocytoma and primary hyperparathyroidism. We report one case with phenotype-genotype mismatch.Observation: Patient A. T is 45 years of age with a family history of thyroid bone marrow cancer (CMT) and sister brain cancer, father colon cancer, with no personal history of disease. A 60 mm long-axis ...

Introduction: Acromegaly is a rare and misdiagnosed disease characterized by somatotropic hypersecretion. The purpose of this study is to describe the epidemiological, clinical, para-clinical, therapeutic features of Acromegaly disease.Patients and methods: This is a retrospective study including 10 patients with acromegaly in the Endocrinology Diabetology Department of Oujda’s Mohammed VI University Hospital, Morocco.Results:...

We present a patient with asymtomatic primary hyperparathyroidism who became normocalcaemic following spontaneous infarction of a parathyroid adenoma. He was referred by the General Practitioner following an episode of renal colic when he was found to have a raised adjusted serum calcium level of 3.07 millimols/litre (ref 2.10-2.70). Parathyroid hormone level was 33.2 picomols/litre (ref 1.3-7.6), confirming primary hyperparathyroidism. A SESTIMIBI scan revealed a parathyroid ...