Endocrine Abstracts

The presentation will provide an introduction to systems biology research and describe the support provided by the UK research councils for research and training in systems biology since 2004/5....

Cranial Diabetes Insipidus is a potentially fatal disorder if not diagnosed and treated appropriately. The diagnosis can either be made in the outpatient setting, whereby the main differential diagnosis is Primary Polydipsia (PP), or during a hospital admission, where patients can be prfoondly unwell, dehydrated and hypernatraemic. In the ouptatient setting, it can sometimes be difficult to distinguish between DI and PP, but usually severe Cranial DI is clinically and biochemi...

Cranial Diabetes Insipidus is a potentially fatal disorder if not diagnosed and treated appropriately. The diagnosis can either be made in the outpatient setting, whereby the main differential diagnosis is Primary Polydipsia (PP), or during a hospital admission, where patients can be prfoondly unwell, dehydrated and hypernatraemic. In the ouptatient setting, it can sometimes be difficult to distinguish between DI and PP, but usually severe Cranial DI is clinically and biochemi...

Background: Incidentally discovered pituitary lesions are a common problem in the endocrinology clinic due to increased access to detailed brain imaging. The challenge for endocrinologists is to determine which pituitary lesions are clinically significant and which are truly incidental. Pituitary micro-adenomas have been found at autopsy in 1.5–27% of subjects, whilst population-based radiological studies report small pituitary lesions in ~10%. It is difficult to produce ...

TEAMeD (Thyroid Eye Disease Amsterdam Declaration Implementation Group UK) was established in 2009 to implement the Amsterdam Declaration, which pledged to improve care for people with TED and prevent TED in those at risk. This autumn, TEAMeD is launching ‘TEAMeD-5’, a campaign to promote better care for patients with, or at risk of TED. This campaign aims to implement 5 key evidence based recommendations in endocrine clinics across the UK....

This will be a personal reflection by an ‘experienced’ clinician who has spent much his consultant career in clinical management including 4 years as Medical Director of a large Acute Trust. I will try and highlight the advantages and benefits of being involved in clinical management for you the Clinician, the Trust and your Patients. I will also outline some of the problems and pitfalls that can arise but I will focus on how this career choice can be developed and b...

TEAMeD (Thyroid Eye Disease Amsterdam Declaration Implementation Group UK) was established in 2009 to implement the Amsterdam Declaration, which pledged to improve care for people with TED and prevent TED in those at risk. This autumn, TEAMeD is launching ‘TEAMeD-5’, a campaign to promote better care for patients with, or at risk of TED. This campaign aims to implement 5 key evidence based recommendations in endocrine clinics across the UK....

This will be a personal reflection by an ‘experienced’ clinician who has spent much his consultant career in clinical management including 4 years as Medical Director of a large Acute Trust. I will try and highlight the advantages and benefits of being involved in clinical management for you the Clinician, the Trust and your Patients. I will also outline some of the problems and pitfalls that can arise but I will focus on how this career choice can be developed and b...

PCOS is associated with increased androgens, elevated insulin and obesity. As obesity and androgens promote insulin resistance and hyperinsulinemia increases ovarian androgen production, and the likelihood of obesity, the interaction between these factors is complex. We investigated the development of insulin resistance, hyperandrogenism and obesity using a clinically realistic ovine model of PCOS. Exposure of the pregnant ewe to increased testosterone from d62 to d102 of gest...

It is nearly 100 years since the discovery of insulin and insulin is still the only treatment we have for type 1 diabetes (T1D). Using and adjusting insulin therapy is very difficult and demanding for patients and rarely allows perfect blood sugar control. Even with recent advances in insulin delivery, less than 30% of patients achieve levels of HbA1c that prevent long-term complications and many of those that do regularly experience hypoglycaemia. Furthermore, a significant n...