Endocrine Abstracts

Introduction: Secondary hormonal deficiencies (SHD) are frequently observed in patients with pituitary adenomas. We previously reported that pituitary tumour clinical subtypes were associated with specific patterns of SHD, and nonfunctioning adenomas (NFAs) were more likely to present with multiple SHD. We extended our work to examine if the immunohistochemical staining patterns of NFAs impacted SHD.Methods: All clinically NFAs surgically removed between...

In March 2020, the world went into covid lockdown. Students, trainees and consultants were all called to the front-line, working additional and highly stressful shifts. Amongst the numerous negative consequences of the pandemic, teaching fell by the wayside. All conferences and educational meetings were cancelled. Initially there seemed no time or mechanism to continue teaching. However, on the 27th April 2020, one month into the first lockdown, I presented the first ‘Ale...

A 37 year old lady presented to her GP with increasing lethergy, bloating and low mood associated with her menstrual periods. Her GP undertook a hormonal screen including androgen profile which revealed elevated 17-Hydroxyprogesterone 25.5 nmol/L (0.1–8.5). The rest of her androgen profile was normal. As a teenager she suffered with acne and hirsutism, for which she had laser therapy, but this had resolved. Periods were regular, every 28 days with 1–2 days menstruati...

11β-hydoxysteroid dehydrogenase type 1 (11β-HSD1) essentially catalyzes the conversion of the inactive endogenous glucocorticoid cortisone (11-dehydrocorticosterone in rodents) and the synthetic prednisone into the active cortisol (corticosterone in rodents) and prednisolone. The association of an elevated expression of 11β-HSD1 with metabolic disease has been extensively studied in humans and in rodent models. It is generally assumed that the effects that are o...

Insulinomas, uncommon neuroendocrine tumours, may produce insulin-induced hypoglycemia. It causes neuroglycopenia and autonomic sympathetic dysfunction. Glucose immediately relieves these sensations. Hypoglycemia without plasma sulfonylurea and increased C-peptide is diagnostic. The tumour must be found before surgery.Introduction: Hypoglycemia is caused by insulinomas. Insulinoma, the most frequent functional pancreatic tumour, occurs just four times pe...

Case History: A 19-year-old female presented with painful left shoulder after slipping whilst doing press-ups. Plain x-ray showed a proximal humeral fracture, as well as a large bone cyst raising concerns of a pathological fracture. She had no past medical history and was not taking any regular medications. On further questioning she did complain of a 2 year history of bilateral painful shoulders and left knee pain. Family history was significant for her father suffering prima...

A 37-year-old Nigerian lady was referred to the endocrinology clinic with worsening dyspnoea, weight loss, poor sleep and palpitations over the preceding few months. She had a past history of depression treated with citalopram. She was clinically and biochemically thyrotoxic with a TSH <0.01 μ/l [0.4–5] and free T4 49.3 pmol/l [9–19]. TSH receptor antibodies were positive. She was commenced on carbimazole 40 mg once daily and propranolol 40 mg twi...

Introduction: The effect of self-prescribed cross-sex hormone therapy on Male-to-Female (MtF) transgenders do not appear to have been well investigated and can be associated with potential serious longterm complications. The main purpose of this study is to look at the clinical and metabolic profile, and cardiovascular outcomes of MtF transgenders in Zamboanga Peninsula.Methodology: This is a cross-sectional study, done to determine the clinical and meta...

Introduction: Formation of immunological tolerance to self antigens is an important mechanism that prevents the development of autoimmune diseases.Methods: With the help of molecular genetic and immunofluorescence techniques we investigated the effects of experimental gestational diabetes (EGD) on the level of mRNA expression of autoimmune regulator Aire and differentiation features of Foxp3+ cells in mesenteric lymph nodes in the offspring of...

Introduction: Type 1 diabetes mellitus is a T-cell mediated autoimmune disease characterized by the destruction of β-cells of the pancreas. Numerous studies have demonstrated the key role of FoxP3+ regulatory T-cells in the development of type 1 diabetes.Aim: The aim of research: 1) to determine the expression patterns of transcription factor FoxP3 in the pancreatic lymph node cells in animal model of diabetes mellitus and 2) to assay an effect of m...