Endocrine Abstracts

Background: The balance between Adrenergic Receptor (AR) subtypes and Atrial Natriuretic Peptide (ANP) is crucial for lipolysis. It was previously demonstrated that ANP is strongly lipolytic and we recently demonstrated that ANP is expressed and secreted by human pre-adipocytes. In previous studies, β-receptor density and lipolysis were higher in human visceral adipose tissue (HVAT) as compared with human subcutaneous adipose tissue (HSAT).Aims and ...

Introduction: Prader Willi syndrome (PWS) is a complex neurodevelopmental genetic condition which is characterised by hyperphagia, endocrine dysfunction, behavioural and psychiatric issues. Current literature recommends a multi-disciplinary approach to PWS management to tackle its multi-faceted manifestations. No previous study has examined the views and satisfaction levels relating to the services provided for children with PWS in Wales.Methods: Semi-st...

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Transient mild hyperthyroidism is fairly common in women with hyperemesis gravidarum, occurring in up to two-thirds of them. It is also a well known fact that pregnant women with severe hyperemesis gravidarum can progress to develop Wernicke’s encephalopathy. Hyperthyroidism, without any other risk factors, has been described to accelerate the process of thiamine depletion as well. This is much less recognised.We describe the case of a 32-year-old P...

Background: Childhood obesity is increasing worldwide and presents as a global health issue due to multiple metabolic comorbidities. About 1% of adolescents with obesity develop type 2 diabetes (T2D), however little is known about the genetic background in young age. The objective of this study was to assess the prevalence of impaired glucose regulation (IGR) in a large cohort of children and adolescents with obesity and to characterize insulin sensitivity and insulin secretio...

Introduction/Purpose: Despite some evidence that women with premature ovarian insufficiency (POI, loss of ovarian activity<40 years of age) are at risk for diminished life expectancy, large scale population-based studies are still scarce. The evidence on whether hormone replacement therapy (HRT) use decreases the mortality risk among women with POI are lacking. The aim of our study was to explore mortality among women with spontaneous POI and their controls in a large nati...

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA), and the same trend is observed in the national quality indicator. The validity of electronic databases and quality indicators are limited by multiple discharges and precision of coding. Furthermore, amputation codes included in the quality indicator do not include all amputations. We therefore aim to investigate the ...

Background: Prolactinomas (PRL) are pituitary adenomas mainly characterized by hyperprolactinemia. In addition to the endocrine effects of prolactin, metabolic alterations have been described in PRL patients. Changes in inflammatory parameters have recently been identified in pituitary adenoma patients. Since both, metabolic (MM) and inflammatory markers (IM) showed promising results in characterization/prognosis of tumor patients, it is tempting to speculate whether those mig...

Background and Aim: Recent international studies indicate a secular decrease in the proportion of patients with diabetes who undergo lower limb amputations (LLA). However, our findings suggest that the proportion of diabetics among patients undergoing non-traumatic, non-cancer related lower limb amputations has increased over the past decades despite comprehensive preoperative investigations and other surgical interventions. To further explore the underlying reasons for this, ...

Recent data suggest that not only caloric density but also macronutrient composition of diets can influence metabolism, body composition and the development of metabolic disorders. A limitation of previous studies was that effects were studied predominantly in males. To better understand potential differences in the response of males and females to manipulations of dietary macronutrients, our studies were undertaken in both sexes. As a dietary model, we used regular chow diet ...