Endocrine Abstracts

Background: Hoping to avoid repeated hypoglycaemia and yo-yo phenomena, alternative feedback was proposed based on the body “energetic balance” evolution checking. A device (ADD-CIT – Apparatus for Diagnosis of Diabetes and Complex Insulin Therapy) measuring the differences between core and superficial temperatures (Dt) evolution and programming insulin delivery was proposed and first-tested (PDT, 2015).Objective: The present work aims at ...

Background: We present an interesting case of a 56 year old male who, during pre–operative work up, was found to have a very low HbA1C 3.1% (10 mmol/mol). The patient was also noted to have mild thrombocytopenia, raised bilirubin and alanine aminotransferase and moderate splenomegaly on CT scan, with otherwise normal appearance of remaining abdominal viscera. His past medical history included alcohol excess (60–80 units/week), he was not diabetic and was taking Asp...

Introduction: Very late step growth is quite rare, and probably very rare, if there is, 10 years after the end of treatment with GH. Therefore, we would like to present our patient, even though we cannot yet give a full pathomechanism of his disorders.Case report: A man 28 years, was admitted to us to assess hormonal status before elective hip surgery. He had congenital brain toxoplasmosis. From 8 to 16 years he was treated with GH without a good effect....

Introduction: The occurrence of primary pituitary tumour and cerebral schwannoma in the same person is very rare. Only few cases have been reported so far. The mechanism of this association is still unclear.Aim: Our aim is to report a man with two different brain tumours: a prolactinoma and a cerebellopontine schwannoma in order to discuss the possible mechanism of multiple neoplasms arising in the same person.Case report: A man ag...

A 31-year-old man without previous medical history presented to his local hospital with one week history of generalised severe headache. Brain CT was reported as negative for acute intracranial pathology. Five weeks later, he re-presented with worsening headache and blurring of vision. Brain CT revealed a large area of hypodensity centred on the left thalamus/basal ganglia and subsequent MRI with contrast showed a medium size pituitary cyst with suprasellar extension and two c...

Introduction: 48, XXYY is a rare sex chromosome aneuploidy, being estimated to occur in 1:18000–1:40000 male births. Phenotypically it was considered a variant of Klinefelter syndrome (47,XXY), but currently, due to mental deficiency and behavioural characteristics associated, it’s considered to be a separated genetic condition.Case report: We report a case of a 8-year-old boy, first child of a young non-consanguineous couple, born at term. Due...

A 71-year-old gentleman was referred for investigation of bilateral enlarged adrenals first discovered after presenting with subacute bowel obstruction. A CT scan of his abdomen revealed the left adrenal was 8×5 cm, the right 3 cm. No other abnormalities were detected.The patient was otherwise well. No other medical history was volunteered. On examination, he was of short stature (height 1.47 m) with a normal pattern of pubic and axillary hair. Bloo...

Thyroid eye disease (TED) is clinically evident in 25–50% of patients with Graves’ disease and 3–5% of cases develop severe eye disease. We present a case of very aggressive TED.A 46-year-old gentleman developed graves thyrotoxicosis and was blocked and replaced with carbimazole and thyroxine. He continued to smoke 20 cigarettes/day despite several advises.He developed marked exophthalmos (L>R), chemosis, with re...

Introduction: Prolactin (PRL) levels > 250 ng/ml are highly suggestive of prolactinomas though they may be also seen in other conditions, particularly macroprolactinemia, GH and PRL cosecreting tumors, and renal failure. Drug-induced hyperprolactinemia is typically associated with mild PRL elevation (usually <100 ng/ml). Higher levels (around 300 ng/ml) have been occasionally reported, particularly with risperidone, an atypical antipsychotic drug.<p class="abstext"...

Currently there is no widely accepted definition of very low-risk papillary thyroid carcinoma (PTC). Although unifocal microcarcinomas without extrathyroidal extension and no local or distant metastases have been recognized as having an excellent overall prognosis the threshold for such a favourable clinical behaviour remains controversial. The study aim was to identify the clinicopathological characteristics of T1 tumours (≤2 cm) presenting a very low-risk of mortality ...